Science subverts cognition!

As we all know, muscle regeneration is a complex process involving several steps and relies on stem cells

Skeletal muscle tissue, the organ responsible for movement, is composed of cells (fibers) with more than one nucleus, which is almost unique in our body

William Roman, the first author of the study and UPF researcher, explained: “Even under physiological conditions, regeneration is essential for muscles to withstand the mechanical stress of contraction, which usually leads to cell damage

"In this study, we discovered an alternative mechanism for muscle tissue repair, which is muscle fiber autonomous," said Pura Muñoz-Cánoves, professor of ICREA, principal investigator of UPF and CNIC, and research leader

Different in vitro injury models and exercise models are used in mice and humans to observe that after injury, cell nuclei are attracted to the injury site to accelerate the repair of contractile units

Pura Muñoz-Cánoves added: “After exercise-induced muscle damage, this muscle fiber self-repair process in mice and humans occurs rapidly, and therefore represents a short-term and highly efficient protective mechanism for repairing minor injuries

In addition to the significance of muscle research, this research also introduces more general concepts of cell biology, such as the movement of the cell nucleus to the injured site

"This discovery is an important advance in understanding muscle biology, physiology (including exercise physiology), and muscle dysfunction

Original search: "Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction" by William Roman, Helena Pinheiro Mafalda R.