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Ketone supplements may be a new therapy to promote brain function in obese patients
Time of Update: 2021-10-21
The new study found that in obese adults, supplementing with ketones three times a day for 14 days can increase blood flow to the brain and improve cognitive functions such as working memory and processing speed .
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Nuocheng Medical and Xijing Hospital develop an innovative treatment plan for hypertrophic cardiomyopathy
Time of Update: 2021-10-21
Thinness and decreased contractility make the obstruction of the left ventricular outflow tract disappear or alleviate, thereby improving the clinical symptoms of patients with hypertrophic cardiomyopathy .
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New hope for stroke treatment: dipeptide molecules that enhance the activity of brain peptidase neurolysin Nln
Time of Update: 2021-10-21
"This summer, the Karamyan research team and the University of Florida collaborator David Ostrov discovered two histidine dipeptides that can selectively enhance the activity of neurolysin ("identify and characterize two structurally related dipeptides, improve neuro The catalytic efficiency of lysin," published in the August 13th issue of the Journal of Pharmacology and Experimental Therapy) .
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Ge Liang's research group from the School of Life Sciences reported on the molecular pathways that new inner membrane interactions regulate the formation of autophagosome membranes
Time of Update: 2021-10-21
On September 24, 2021, Ge Liang's research group at Tsinghua University published an online publication titled "TMED9 and SEC12 Protein Interaction Mediates ERGIC-ERES New Inner Membrane Interaction to Regulate Autophagosome Membrane in Cell Research" on September 24, 2021.
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"PNAS" new oral antiviral compound prevents SARS-CoV-2 from entering cells
Time of Update: 2021-10-21
The picture shows a compound called MM3122 (yellow), which blocks the active site of the human protein TMPRSS2, which is hijacked by the virus to enter human cells .
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Nature: Toxic fatty acids are the culprit of brain cell death after injury
Time of Update: 2021-10-21
"Our research results show that the toxic fatty acids produced by astrocytes play a key role in brain cell death and provide a promising new target for the treatment or even prevention of many neurodegenerative diseases," the study said.
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The agro-ecological team proposes a sustainable development strategy for the rice shrimp model
Time of Update: 2021-10-21
Nanhu News Network (correspondent Jiang Yang) Recently, the agricultural ecology research team of the School of Plant Science and Technology of our school published a review, telling the story of the development of the rice shrimp model in China, and comprehensively analyzed the environmental and ecological effects, economic effects and social effects of the rice shrimp model , Put forward the principles and technical strategies of the sustainable development of the Chinese rice shrimp model .
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Single-molecule RNA sequencing simultaneously detects multiple RNA base modifications
Time of Update: 2021-10-21
Now, a research team from Osaka University has proposed a single-molecule quantum sequencer that can detect RNA base modifications in microRNA, such as N6-methyladenosine (m6A) or 5-methyl Cytidine (5mC), these modifications are related to cancer cell proliferation and inhibition .
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Chinese scholars have made progress in the catalysis of alkynes with chiral organic acids
Time of Update: 2021-10-21
Chiral Br?nsted acid activates alkynyl group to construct chiral spiro ring With funding from the National Natural Science Foundation of China (approval numbers: 92056104, 21772161, 2170
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"Nature Aging" Can an approved drug prevent and treat Alzheimer's disease?
Time of Update: 2021-10-21
Finally, when the researchers studied the effect of the drug on human neurons from the skin cells of Alzheimer's patients carrying the APOE4 gene, they found that bumetanide reversed the changes in gene expression associated with the disease .
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2021 Anesthesiology Annual Conference: Acupuncture can reduce pain and opioid use in patients undergoing total knee arthroplasty by 65%
Time of Update: 2021-10-21
"Total knee arthroplasty is one of the most common surgical procedures in the United States and is usually very painful, so it is very necessary to explore non-opioid analgesia techniques for this type of surgery .
Historically, only 9% of non-study patients maintained low-dose or no opioid therapy after surgery .
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Chinese scholars and overseas collaborators have made important progress in the study of key reactions in nuclear astrophysics in the Deep Earth Laboratory
Time of Update: 2021-10-21
The deep laboratory can greatly reduce the interference of cosmic rays and provide a measurement environment with extremely low background, which is conducive to the accurate measurement and research of rare reaction events .
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Chinese Academy of Sciences scholar Immunity published a paper: MDA5-MAVS antiviral signaling pathway assembly program and activation mechanism
Time of Update: 2021-10-21
This research fills up the gaps in the study of MDA5 pathway activation and signal transduction, and further reveals the immunological function of long-chain, non-anchored K63-polyUb as an endogenous agonist in the cell, in order to understand the molecular diversity of ubiquitin in anti-RNA The role of viral innate immune signal transduction and regulation provides new clues .
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Metabonomic analysis of different mice showed that liver arginase-1 is the source of plasma arginase in Plasmodium infection
Time of Update: 2021-10-21
Our findings support the use of different mice to understand the link between metabolism during infection and disease severity, and promote further research on the metabolic consequences of human malaria liver damage .
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Results of Phase I Trial of Allogeneic CD7 CAR-T Treatment of T-cell Leukemia Announced
Time of Update: 2021-10-21
Recently, the team of Director Pan Jing from Beijing Boren Hospital published an article in the Journal of Clinical Oncology, introducing the data of the first single-center phase I trial of r/r T-ALL with anti-CD7 CAR-T cell therapy, proving allogeneic health Donor-derived anti-CD7 CAR-T cells are safe and have an impressive short-term efficacy .
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Gorilla can distinguish human voice
Time of Update: 2021-10-21
Apes may judge threats by their familiarity with human voicesIn about 6 months, the research team played three groups of orangutan recordings: one group was a long-term breeder, who knew and worked with gorillas for at least 4 years, and had a positive relationship with them; people the apes knew , Including veterinarians and maintenance personnel, but have had bad interactions with them; and those who are not familiar with animals .
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The Liu Yule laboratory of the School of Life Sciences has developed a virus-induced gene silencing system that can quickly and efficiently study the function of maize genes.
Time of Update: 2021-10-21
On September 21, 2021, the Liu Yule Laboratory of Tsinghua University published an online publication titled "High-efficiency and high-throughput virus-induced maize gene silencing system based on pseudo-recombinant chimeric cucumber mosaic virus" in the journal Plant Physiology.
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The common "cough virus" actually manipulates host immune genes
Time of Update: 2021-10-21
The viral protein NS1 (green) is found in the nucleus (blue) of human respiratory cilia cells (red shows cilia) infected with respiratory syncytial virus (RSV) .
When cells are infected by a virus, the expression of immune response genes is very high .
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Microbiome: Battle of Bacteria
Time of Update: 2021-10-21
Stecher and her research team have now investigated how these strains protect their hosts from Salmonella infection .
In order to cause infections, pathogenic bacteria must find a suitable niche in the intestines to provide them with carbon sources needed for replication, such as certain sugars .
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The Ou Guangshuo Laboratory of the School of Life Sciences reported the regulatory role of microfilament skeleton debranching in cell migration and asymmetric cell division
Time of Update: 2021-10-21
These results indicate that in migrating neural precursor cells and asymmetrically dividing embryos, the cells organize microfilament networks and cell polarity through microfilament debranching (Figure 2) .
In migrating neural precursor cells and asymmetrically dividing embryos, cells debranching through microfilaments to organize microfilament networks and cell polarity Figure 1.
