With funding from the National Natural Science Foundation of China (approval numbers: 92056104, 21772161, 21702182 and 21873085), Professor Ye Longwu of Xiamen University and Zhejiang University researcher Hong Xin have made important progress in the catalysis of alkynes with chiral organic acids
Link to the paper: https://
The catalysis of chiral Brönsted acids represented by chiral phosphoric acid is one of the most active research directions in the field of asymmetric organic catalysis in recent years, but previous reports mainly used carbon-heteroatom-containing double bonds (such as Carbonyl or imine, etc.
The research started from the alkyne amide substrates containing hydrogen bond donor aryl substitutions, using commercially available chiral phosphoric acid as a catalyst, and successfully achieved the catalytic asymmetric dearomatization based on the activated carbon-carbon triple bond of chiral phosphoric acid.
This research not only provides a new activation mode for chiral organic acid catalysis, but also provides a new method for the highly enantioselective synthesis of pharmaceutical active molecules
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