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The Liu Yule laboratory of the School of Life Sciences has developed a virus-induced gene silencing system that can quickly and efficiently study the function of maize genes.
Time of Update: 2021-10-21
On September 21, 2021, the Liu Yule Laboratory of Tsinghua University published an online publication titled "High-efficiency and high-throughput virus-induced maize gene silencing system based on pseudo-recombinant chimeric cucumber mosaic virus" in the journal Plant Physiology.
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The Ou Guangshuo Laboratory of the School of Life Sciences reported the regulatory role of microfilament skeleton debranching in cell migration and asymmetric cell division
Time of Update: 2021-10-21
These results indicate that in migrating neural precursor cells and asymmetrically dividing embryos, the cells organize microfilament networks and cell polarity through microfilament debranching (Figure 2) .
In migrating neural precursor cells and asymmetrically dividing embryos, cells debranching through microfilaments to organize microfilament networks and cell polarity Figure 1.
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Molecular mechanism of RAG cell periodic regulation in Cell Reports V(D)J rearrangement
Time of Update: 2021-10-21
This indicates that the rearrangement enzyme activity of RAG1 in cells is regulated by the state of self-aggregates, which can also explain how developing lymphocytes protect the integrity of their own genome outside the G1 cycle .
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Science: Gut bacteria can cause prostate cancer growth and treatment resistance
Time of Update: 2021-10-21
found that androgen deprivation in prostate cancer patients and mouse models promoted the proliferation of specific intestinal bacteria that can synthesize androgens, leading to continued tumor growth in mice .
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Chinese scholars have made progress in the field of bionic vision adaptation
Time of Update: 2021-10-21
Figure 1 (a) Schematic diagram of the principle of human visual adaptation, (b) OAAT device structure diagram, (c) OAAT light intensity dependent adaptability curve With funding from the National Natural Science Foundation of China (approval numbers: 22021002, 62075224, 62001454), the team of researchers Zhu Daoben and researcher Di Chongan from the Institute of Chemistry of the Chinese Academy of Sciences has made progress in the field of bionic vision adaptation .
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Oncotarget: Targeting the TP53 mutation of NGS in breast cancer
Time of Update: 2021-10-21
This case-control study shows that the somatic mutation of TP53 detected by next-generation sequencing is associated with the poor prognosis of breast cancer .
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Cell Journal: Looking for a bacterial cocktail to fight infection
Time of Update: 2021-10-21
Oxytocin can specifically exclude multi-drug resistant Klebsiella pneumoniae, because it effectively prevents the niche occupied by hospital bacteria .
" Scientists also found in mice that these bacteria contribute to the bacterial composition in the intestines Regenerate faster after antibiotic treatment and ensure that protection against infection is restored .
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Cancer drug response and results can be predicted by changes in cell clumps
Time of Update: 2021-10-21
"In the current study, the researchers verified the response of 69 patients with aggressive brain cancer (glioblastoma) neurosphere models to the chemotherapy drug temozolomide using existing matching data on patient survival and genomics.
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Gene editing makes "ready-to-use" CAR-T therapy Phase 1 clinical trial results are positive
Time of Update: 2021-10-21
▲Introduction of CTX110 (picture source: CRISPR Therapeutics)In this clinical trial, a total of 26 large B-cell lymphoma patients received CTX110 treatment and were followed up for at least 28 days .
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Herui Gene was invited to participate in IBIWS and released the latest research results of early screening of multiple cancers
Time of Update: 2021-10-21
Relying on the excellent performance and general characteristics of the platform-based underlying technology HIFI, following the major breakthrough of "from 0 to 1" in the early screening of liver cancer, Herui Gene has once again taken a solid step "from one to many": one test achieves six major China For the early screening of high-risk cancers, all detection indicators have reached or exceeded the international advanced level .
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China's scientific and technological anti-epidemic practice is highly praised by "Nature" magazine
Time of Update: 2021-10-21
"Under the scientific and technological innovation and model changes in the field of health care driven by China's informatization and digitalization, Chinese scholars have achieved a series of world-renowned research results in the'anti-epidemic science and technology' and'remote prevention and treatment of chronic diseases' through the cross-cooperation of information and medicine.
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This new website helps to study the genetic basis of type 2 diabetes
Time of Update: 2021-10-21
TIGER's analysis showed that certain genetic variants in pancreatic islets in type 2 diabetes control the expression of specific genes .
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Identify key pathogenic proteins in Alzheimer's disease, Harvard scientists develop important detection tools
Time of Update: 2021-10-21
. Recently, scientists have developed a sensitive detection method specifically designed to identify and quantify Aβ oligomers in the human brain, cerebrospinal fluid, and blood .
, (2021) An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma.
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"Nature Aging" Can an approved drug prevent and treat Alzheimer's disease?
Time of Update: 2021-10-21
Finally, when the researchers studied the effect of the drug on human neurons from the skin cells of Alzheimer's patients carrying the APOE4 gene, they found that bumetanide reversed the changes in gene expression associated with the disease .
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The "ideal blood pressure" that helps delay the aging of the brain!
Time of Update: 2021-10-21
The study published by the Australian National University in Frontiers in Aging Neuroscience found that participants with high blood pressure had older brains and were therefore less healthy, increasing their risk of heart disease, stroke and dementia .
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New research from Nature confirms that mRNA vaccines are effective against 16 mutated new coronaviruses including Delta
Time of Update: 2021-10-21
The Yale University research team tested blood samples from vaccinators and confirmed that two existing mRNA vaccines can enhance the immune system’s response to infection and prevent more than a dozen new coronavirus variants, including the delta variant .
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Nature sub-issue: Epithelial cells use MHC-II molecules to coordinate lung immunity
Time of Update: 2021-10-21
According to a research published by scientists in Nature Communications ("The antigen presentation of lung epithelial cells guides CD4+ TRM cell function and regulates barrier immunity"), this type of epithelial MHC-II is called resident memory T (TRM) The highly specialized immune cells of lymphocytes are essential .
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A new post-translational modification: What is the reason for protein lactosification?
Time of Update: 2021-10-21
This paper shows that protein lactosylation in brain cells is regulated by neural activation and social failure stress, parallel to changes in lactic acid levels .
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Droplets growing in the matrix
Time of Update: 2021-10-21
In this model, researchers use temperature modulation to study the effects of phase separation and droplet formation .
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Nature Sub-Journal: Simultaneous optical and electrical tracking of heart activity
Time of Update: 2021-10-21
In order to conduct a comprehensive optogenetic study of the heart, researchers led by Stephan Rohr of the Department of Physiology at the University of Bern developed a new experimental system called the "Panoramic Photoelectric Measurement and Stimulation (POEMS)" system .
