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The intestinal microbes of patients receiving androgen deprivation therapy (ADT) to treat advanced prostate cancer and microbes in similar mouse models can produce androgens that circulate in the body This discovery by Nicolò Pernigoni and colleagues can help explain why some patients develop ADT resistance, and may develop treatments for the gut microbiota to overcome this resistance Androgens promote the growth of prostate tumor cells, and ADT is the most commonly used treatment for patients with advanced prostate cancer However, patients usually develop resistance to ADT, leading to tumor growth and poor prognosis The researchers also found that fecal transplants from patients and mice that are still sensitive to ADT can control tumor growth in drug-resistant mice John McCulloch and Giorgio Trinchieri discuss these results in related literature |
DOI
10.
1126/science.
abf8403
Article title
Commensal bacteria promote endocrine-resistance in prostate cancer via androgen biosynthesis
