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Science: Gut bacteria can cause prostate cancer growth and treatment resistance
Time of Update: 2021-10-21
found that androgen deprivation in prostate cancer patients and mouse models promoted the proliferation of specific intestinal bacteria that can synthesize androgens, leading to continued tumor growth in mice .
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A new post-translational modification: What is the reason for protein lactosification?
Time of Update: 2021-10-21
This paper shows that protein lactosylation in brain cells is regulated by neural activation and social failure stress, parallel to changes in lactic acid levels .
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"Nature Aging" Can an approved drug prevent and treat Alzheimer's disease?
Time of Update: 2021-10-21
Finally, when the researchers studied the effect of the drug on human neurons from the skin cells of Alzheimer's patients carrying the APOE4 gene, they found that bumetanide reversed the changes in gene expression associated with the disease .
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New research from Nature confirms that mRNA vaccines are effective against 16 mutated new coronaviruses including Delta
Time of Update: 2021-10-21
The Yale University research team tested blood samples from vaccinators and confirmed that two existing mRNA vaccines can enhance the immune system’s response to infection and prevent more than a dozen new coronavirus variants, including the delta variant .
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Nature Sub-Journal: Simultaneous optical and electrical tracking of heart activity
Time of Update: 2021-10-21
In order to conduct a comprehensive optogenetic study of the heart, researchers led by Stephan Rohr of the Department of Physiology at the University of Bern developed a new experimental system called the "Panoramic Photoelectric Measurement and Stimulation (POEMS)" system .
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Unlock the secrets of jellyfish eating
Time of Update: 2021-10-20
Unique isotope and fatty acid "signatures", also known as "biomarkers", are passed from prey to predator and can be used to trace the connection of the food web and clarify the composition of the animal's diet .
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Chinese Academy of Sciences scholar Advanced Science published a paper: Oncogene NEAT1 inhibits the occurrence and development of leukemia
Time of Update: 2021-10-20
The researchers found that NEAT1 located in the side spots shuttles from the nucleus to the cytoplasm, and binds to the Wnt pathway linker protein DVL2 and E3 ubiquitination ligase Trim56, which promotes the degradation of DVL2 and inhibits the Wnt signaling pathway, thereby inhibiting the self-renewal of AML stem cells.
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Brief. Bioinformatics Tang Fuchou and Li Tiejun's research group collaborated to develop a new method for integrating single-cell data based on molecular network features
Time of Update: 2021-10-20
In order to solve the above problems, on September 21, 2021, the Beijing Future Gene Diagnosis Advanced Innovation Center, Peking University Biomedical Frontier Innovation Center Tang Fuchou's research group and Peking University School of Mathematics Li Tiejun's research group jointly published online on Briefings in Bioinformatics entitled Integrating single-cell datasets with ambiguous batch information incorporating molecular network features by research papers .
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Science fiction comes true?
Time of Update: 2021-10-20
Now, German scientists have developed another method to provide oxygen by introducing algae into the tadpole’s blood, allowing the tadpole to "breathe" .
Why are there no vertebrates like frogs?To explore this possibility, the research team injected green algae (Chlamydomonas) or cyanobacteria (Syechocystis) into the heart of tadpoles .
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Clarification of research contradictions: the relationship between diabetes and dementia risk
Time of Update: 2021-10-20
A longitudinal study by the Karolinska Institute in Sweden showed that poorly controlled type 2 diabetes mainly increases the risk of cognitive impairment and dementia, rather than diabetes itself .
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The He Ming team of the School of Basic Medical Sciences reveals new mechanisms and new therapeutic targets for alcoholic liver disease?
Time of Update: 2021-10-20
On October 12th, the team of Professor Ming He from the Department of Pathophysiology and the Key Laboratory of Cell Differentiation and Apoptosis of the Ministry of Education, Shanghai Jiaotong University School of Medicine, published an online publication titled "SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevention" in Cell Discovery.
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Cancer Cell Zhang Zemin's research group and collaborators reveal the mechanism of action of anti-PD-L1 immunotherapy combined with chemotherapy in triple-negative breast cancer
Time of Update: 2021-10-20
October 14, 2021, Biological forefront of innovation Medical Center (BIOPIC) Peking University, College of Life Sciences, Beijing future genetic diagnosis sophisticated Innovation Center (ICG) Zhang
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On October 12, 2021, Fang Dong’s laboratory clarified in Nature Communications that H3K27me3 as a key regulatory factor plays an important role in the asymmetric cell division process induced by Wnt3a
Time of Update: 2021-10-20
Using SET-seq , the authors conducted an in-depth analysis of the asymmetric division of mouse embryonic stem cells induced by Wnt3a , and revealed the gene regulation mechanism that maintains and resets the fate of stem cells during the differentiation process .
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Immune response to infections and diseases, gender is important
Time of Update: 2021-10-20
Irahi and his team studied how anemia (a disease in which the human body lacks enough mature red blood cells to carry oxygen) is caused by iron deficiency or blood loss, and produces different immune responses in men and women .
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Target CD47: The fiery track attracts the crowds to compete and differentiated competition becomes increasingly obvious
Time of Update: 2021-10-20
Clinical stage CD47 antibody/fusion protein drugs03 Targeting SIRPα03 Targeting SIRPαThe main advantage of targeting SIRPα to block the CD47-SIRPα checkpoint is that SIRPα has limited tissue distribution and is not expressed on red blood cells.
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Stem cell transplantation: how skin-derived T cells damage other organs
Time of Update: 2021-10-20
In skin samples from patients before and after transplantation, Stary and research author Johanna Strob were able to prove that host-derived T cells in the skin tissue are responsible for the inflammation .
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Fungi can survive the winter safely, thanks to these cells
Time of Update: 2021-10-20
nidulans ) (shown in pink here), surrounded by Hülle cells According to a study published in the journal eLife, scientists have discovered a new role for a known cell that cultivates the overwintering reproductive structure in a fungus .
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Migraines caused by changes in metabolite levels
Time of Update: 2021-10-20
Professor Niholt said the research team identified three causal genetic links between blood metabolite levels and increased migraine risk:Reduce the level of DHA, which is an omega-3 fatty acid that can reduce inflammationHigher levels of LPE (20:4), LPE is a chemical that blocks anti-inflammatory moleculesThe third, lower level metabolite that has not yet been identified, is named X-11315 .
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FDA approves Withings smart watch to detect atrial fibrillation and sleep apnea
Time of Update: 2021-10-20
S. Food and Drug Administration (FDA) for detecting atrial fibrillation and measuring blood oxygen levels to prompt night breathing problems .
Users can monitor blood oxygen levels and detect respiratory problems through the SpO2 sensor built into ScanWatch .
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Nature research paves the way for safer opioids
Time of Update: 2021-10-20
Michael Bruchas, Professor of Anesthesiology and Pain Medicine at the University of Washington, said: “Mu-Opioids act on specific receptors in the brain like morphine, like a key to a lock .
