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Image: QUT researchers Professor Dale Nyholt (right), Hamzeh Tanha (middle) and Anita Sathyanarayanan (left) from the QUT Genomics and Personalized Health Center.
Migraine is a pain in the head and buttocks, but the newly discovered genetic cause by QUT researchers may lead to new preventive drugs and treatments
The results of the genetic analysis were published in the American Journal of Human Genetics.
Professor Niholt said the research team identified three causal genetic links between blood metabolite levels and increased migraine risk:
Reduce the level of DHA, which is an omega-3 fatty acid that can reduce inflammation
Higher levels of LPE (20:4), LPE is a chemical that blocks anti-inflammatory molecules
The third, lower level metabolite that has not yet been identified, is named X-11315
Professor Niholt said that future research and clinical trials can target these genetic connections to develop and test compounds that affect metabolite levels and prevent migraine
He said that it is estimated that migraine causes US$35.
Professor Niholt said: "The observed relationship between the genetic factors affecting blood metabolite levels and the genetic risk of migraine shows that the metabolites of migraine patients have changed
Metabolites are substances produced or used by the body when it breaks down food, drugs, or chemicals in the metabolic process
Professor Niholt said: "The changes in blood metabolite levels may be related to diet, life>
Professor Niholt said that in addition to docosahexaenoic acid (DHA), patients with migraine have a higher content of shorter-length fatty acids.
He said: "Fatty acids are composed of more complex lipids.
"Low DHA levels are related to inflammation, cardiovascular and brain diseases, such as depression, which are all related to migraine risk
Professor Niholt said that LPE (20:4) is a chemical compound that prevents the production of an anti-inflammatory molecule called anandamide
"If LPE (20:4) is controlled, allowing more anandamide to be produced to reduce inflammation, this may prevent migraines," he said
Professor Niholt said that lowering the blood level of the third metabolite named X-11315 will also increase the risk of migraine, which is an area of future research
.
DOI
10.
1016/j.
ajhg.
2021.
09.
011
Article title
Genetic overlap and causality between blood metabolites and migraine
