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When a gene is transcribed into RNA, the bases that make up the RNA molecule will be modified, thereby affecting its structure and function
In recent years, epitranscriptomics has been an active research field
Now, a research team from Osaka University has proposed a single-molecule quantum sequencer that can detect RNA base modifications in microRNA, such as N6-methyladenosine (m6A) or 5-methyl Cytidine (5mC), these modifications are related to cancer cell proliferation and inhibition
This article entitled "Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC" was published in the "Scientific Reports" magazine at the end of September
MicroRNAs are small non-coding RNA molecules that play a regulatory role by interfering with and inhibiting gene expression
Researchers at Osaka University first isolated microRNA from colorectal cancer cells and then sequenced individual RNA molecules
Here, they paid attention to two common modifications, m6A and 5mC, which are the addition of a methyl group to adenosine (A) and cytosine (C), respectively
Not only that, but the results they observed indicate that these two types of modifications can influence each other
This work provides a powerful new tool for sequencing various types of RNA base modifications
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Ohshiro, T.
