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New hope for stroke treatment: dipeptide molecules that enhance the activity of brain peptidase neurolysin Nln
Time of Update: 2021-10-21
"This summer, the Karamyan research team and the University of Florida collaborator David Ostrov discovered two histidine dipeptides that can selectively enhance the activity of neurolysin ("identify and characterize two structurally related dipeptides, improve neuro The catalytic efficiency of lysin," published in the August 13th issue of the Journal of Pharmacology and Experimental Therapy) .
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Ge Liang's research group from the School of Life Sciences reported on the molecular pathways that new inner membrane interactions regulate the formation of autophagosome membranes
Time of Update: 2021-10-21
On September 24, 2021, Ge Liang's research group at Tsinghua University published an online publication titled "TMED9 and SEC12 Protein Interaction Mediates ERGIC-ERES New Inner Membrane Interaction to Regulate Autophagosome Membrane in Cell Research" on September 24, 2021.
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Treatment of liver malignant tumors usher in a new interventional treatment plan
Time of Update: 2021-10-21
Dong Jiahong said that the precise manipulation of yttrium [90Y] resin microspheres by doctors to achieve down-stage treatment or potential radical treatment of patients with advanced liver cancer is a landmark advanced achievement in the history of liver cancer treatment in China .
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CRISPR/Cas9 directed epigenetic editing reveals multiple transcriptional regulation and functional effects
Time of Update: 2021-10-21
Here, the author uses CRISPR/dCas9 technology to adapt to epigenetic editing through site-specific targeting of DNA methylation to describe the transcriptional changes of candidate genes and the functional impact on cell fate under different tumor environments .
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FDA approves Dextenza for the treatment of itching eye associated with allergic conjunctivitis
Time of Update: 2021-10-21
S. Food and Drug Administration (FDA) has approved its Supplemental New Drug Application (sNDA), expand the label of Dextenza (dexamethasone sustained-release punctal plug), and increase the treatment of allergic conjunctivitis-related ocular areas.
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Researchers find warning signs of dementia in the blood
Time of Update: 2021-10-21
If dementia is detected early, the chances of having a positive impact on the disease process will increase,” André Fischer said.
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Scientists report evidence of a new but now extinct species of ancient terrestrial sloth
Time of Update: 2021-10-21
The evidence was first discovered in January 2009, when divers found the bones of a sloth in a flooded cave on the island of Hispaniola (now home to the Dominican Republic and Haiti) .
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The joint team of Wang Hui and Li Xiaoguang of the School of Public Health found that benign psychological stress passes SNS/β-ARs/CCL2...
Time of Update: 2021-10-21
in mice " paper, the study found that benign psychological stress enhances anti-tumor immune response through SNS/β-ARs/CCL2 signaling pathway, thereby inhibiting the occurrence and development of liver cancer and overcoming PD-L1 immunotherapy resistance, which is a psychological and emotional factor The theoretical research and clinical guidance on the role of cancer prevention and control provide new insights .
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The latest paper of Huazhong Agricultural University: A new high-throughput gene editing technology
Time of Update: 2021-10-21
In this study, the research group designed 12 CRISPR/Cas vectors containing different FLASH tags, and combined them with 96-well plate high-throughput cloning technology to establish a method for rapid construction of Cas9/gRNA plasmid libraries .
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The more severe the symptoms at the time of infection, the "deeper" the new crown immune memory
Time of Update: 2021-10-21
Can the immune system in our body "remember" after resisting the attack of the new coronavirus? If so, is there a chance of life-long immunity after being infected with the new crown? If not, then how
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Eleva advances clinical development of difficult-to-express high-potential proteins
Time of Update: 2021-10-21
Freiburg, Germany, October 12, 2021/PRNewswire/ - The outstanding biologics manufacturer Eleva is advancing its drug candidates (such as immunomodulatory factor H) into the clinical phase and is cooperating with many pharmaceutical partners .
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Merck builds contract development and manufacturing facility for new viral vectors
Time of Update: 2021-10-21
Merck today announced the opening of its second facility in Carlsbad, California, which will more than double the company's existing capacity to support large-scale commercial and industrial manufacturing of viral gene therapies .
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Cell uncovers the mystery of touch: why certain body parts are so sensitive
Time of Update: 2021-10-21
But how does the connection between sensory neurons and the brain produce such sensitive skin?A new study led by researchers at Harvard Medical School has revealed a mechanism that may be the reason why certain skin areas are more sensitive .
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Nature Biotechnology: A new tool to understand how the genome is organized in a single cell
Time of Update: 2021-10-21
This algorithm is the first tool to use complex neural networks on hypermaps to provide high-resolution analysis of single-cell genome organization .
Higashi provides a more detailed analysis of the complex organization and biological processes of chromatin organization in a single cell, and how its interaction changes between cells .
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Freeze the zoo to save the animals
Time of Update: 2021-10-21
"On the contrary, the researchers hope to use assisted reproductive technology to integrate the sperm of the biobank into captive populations, so as to make people realize the "great potential" of saving money, reduce the number of captive animals required for breeding projects, and use existing resources Protect more species .
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Ketone supplements may be a new therapy to promote brain function in obese patients
Time of Update: 2021-10-21
The new study found that in obese adults, supplementing with ketones three times a day for 14 days can increase blood flow to the brain and improve cognitive functions such as working memory and processing speed .
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"PNAS" new oral antiviral compound prevents SARS-CoV-2 from entering cells
Time of Update: 2021-10-21
The picture shows a compound called MM3122 (yellow), which blocks the active site of the human protein TMPRSS2, which is hijacked by the virus to enter human cells .
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Chinese scholars found that volcano-driven climate change caused the rise of dinosaurs
Time of Update: 2021-10-21
With funding from the National Natural Science Foundation of China (approval numbers: 41772161, 41472131), Shao Longyi and Lu Jing’s team from the School of Earth Sciences and Surveying and Mapping Engineering of China University of Mining and Technology (Beijing) conducted the Late Triassic Carnian Langoria Great Igneous Rock Provincial research on the terrestrial environment-climate driving effect .
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Schaeffler takes the lead in the German hydrogen energy project to help the industrial development of hydrogen production technology
Time of Update: 2021-10-21
The goal of this sub-project is to develop large-scale innovative technology and production for PEM low-temperature electrolytic reactor In the growing hydrogen energy market, Schaeffler’s expertise in production technology and electrochemistry is the key to successSchweinfurt, October 12, 2021/PRNewswire/ - The green hydrogen energy industry chain is the key to achieving carbon neutrality and sustainable development in the future, and it has great potential in addressing climate change .
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The antiviral principle of Merck's Molnupiravir, how safe and mutagenic is it?
Time of Update: 2021-10-21
This article will focus on analyzing the antiviral principles of Molnupiravir, and then based on these principles, how to treat the safety of the drug, especially the risk of mutation .
Because nucleoside analogs need to consider the risk of mutations, scientists also did related experiments when studying EIDD-1931 .
