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Science: ivory hunting promotes the evolution of toothless elephants
Time of Update: 2021-11-02
Mathematical modeling by Shane Campbell-Staton, an evolutionary biologist at Princeton University in New Jersey, and his colleagues confirmed that this transition was the result of hunting pressure: the selective killing of ivory elephants resulted in more ivory-free elephants.
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The real crab that fills the key gap in evolution
Time of Update: 2021-11-02
"However, Luque and his team were a bit lucky because the amber found in the jungles of Southeast Asia provided researchers with the opportunity to study a particularly complete sample, believed to be the oldest modern-looking crab discovered so far .
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Science: Bacteria can switch their immune functions at an alarming rate to fight viruses
Time of Update: 2021-11-02
This study shows that bacteria have exchangeable genetic elements that are specifically designed to defend against viruses, allowing bacterial populations to switch their innate immune functions at an alarming rate .
"Our research shows that these defense genes are exchanged very quickly between bacterial cells .
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Cancer Cell: Many patients with double vaccinations have poor immune response
Time of Update: 2021-11-02
The author believes that in the absence of the protection usually provided by vaccines, this study shows the importance of continuing to take public health measures to limit the spread of SARS-CoV-2, and the urgency of strengthening the plan, especially in the United Kingdom delta type When the virus spreads highlyPatients with solid cancers, such as breast cancer, urology, or skin cancer, also respond poorly to a single dose of the vaccine, with a seroconversion rate of only 38% .
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Cell overcomes limitations and proposes a better gene delivery system
Time of Update: 2021-11-02
The research team led by Sharif tabeborbar developed MyoAAV, a new family of viral vectors that may provide safer gene therapies for inherited muscle diseases .
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New gene therapy platform-a way to treat blindness
Time of Update: 2021-11-02
To solve this problem, the researchers developed a computing platform called scAAVengr, which uses single-cell RNA sequencing to quickly and quantitatively evaluate-among dozens of options-which adeno-associated viral vector (AAV) is the best It is suitable for delivering gene therapy to specific parts of the retina .
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This treatment can enhance the anti-leukemia effect of bone marrow transplantation and reduce recurrence
Time of Update: 2021-11-02
In addition, they are seeking to conduct a randomized trial and may also explore interferon in other types of transplants or blood cancers .
Type-1 Interferon to Prevent Leukemia Relapse after Allogeneic Transplantation .
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Antibody therapy for MIS-C works by depleting inflammatory immune cells
Time of Update: 2021-11-02
After IVIG treatment, these activated neutrophils in patients with misc or Kawasaki disease were significantly reduced .
However, more work is needed to understand how IVIG causes the cell death of these activated neutrophils, and why some misc patients require additional anti-inflammatory treatment .
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The genetic cause of type 1 diabetes may be lung
Time of Update: 2021-11-02
Scientists led by Professor Justin O'sullivan searched for patterns in a huge database of genomic data, and used machine learning to sort gene mutations related to type 1 diabetes, based on the magnitude of the disease impact they produce through different tissues of the human body .
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Moderna initiates phase III clinical recruitment of 6900 subjects for cytomegalovirus mRNA vaccine
Time of Update: 2021-11-02
Article source: Medical Rubik's Cube InfoAuthor: Shi BeiOn October 20, Moderna registered the efficacy, safety and immunogen of its cytomegalovirus (CMV) mRNA vaccine mRNA-1647 in 16-40 year old female healthy subjects on the US clinical trial website (ClinicalTrials.
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Central South University Cell Metabolism publishes a paper: Senescent cells release granular calcineurin to promote bone aging
Time of Update: 2021-11-01
With funding from the National Natural Science Foundation of China (approval numbers: 81930022, 91749105, 81922017), the Luo Xianghang team at Xiangya Hospital of Central South University has made progress in the research of osteoporosis prevention and treatment .
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Studies have found that red blood cells play a greater role in the immune system through their DNA binding ability
Time of Update: 2021-11-01
Acute inflammatory anemia usually appears in the early stages of infection, such as parasitic infections that cause malaria," said senior author Nilam Mangalmurti, MD, an assistant professor of medicine at the University of Pennsylvania .
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Shandong University's latest article: Mechanism of action of lncRNA THAP7-AS1 that promotes gastric cancer metastasis
Time of Update: 2021-11-01
Recently, the team of Professor Gao Peng of Shandong University School of Basic Medicine published in Cell Death & Differentiation (Chinese Academy of Sciences, IF: 15.
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Researchers mapped neurons in the brain that socially interact with other people in the group
Time of Update: 2021-11-01
At the same time, the researchers recorded the activity of individual neurons in a brain region called the dorso-medial prefrontal cortex (dmPFC), which is thought to play a role in social cognition .
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For small cell lung cancer!
Time of Update: 2021-11-01
Reference materials:[1] The Phase 2 clinical study of Pranabrin combined with nivolumab + ipilimumab in the treatment of third-line relapsed small cell lung cancer patients with previous immune checkpoint inhibitors failed to complete the first patient administration.
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Laboratory cultivation of "mini brains": potential treatments for motor neuron disease and frontotemporal dementia
Time of Update: 2021-11-01
By cultivating small organ models of the brain, researchers can understand what happens in the early stages of ALS/FTD (long before symptoms appear) and screen potential drugs .
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Science releases a big leap in the use of iron catalysts in pharmaceuticals
Time of Update: 2021-11-01
Professor Michael Nedig said that Aguilera’s analysis “established a framework for the continued development of iron-based reactions in a rational and mechanically driven way .
" Her analysis "established a framework to continue to develop iron-based reactions in a rational, mechanically driven way," he added .
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MIT's technology to reveal how cancer spreads
Time of Update: 2021-11-01
"By exchanging blood between mice and simultaneously counting CTCs in real time, we obtain a direct measurement of the speed at which CTCs enter the circulation and how long it takes for them to be cleared," Professor of Engineering in the Department of Bioengineering and Mechanical Engineering, Koch General Said Scott Manalis, a member of the Cancer Institute and senior author of the study .
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Review how the tumor microenvironment affects immunotherapy?
Time of Update: 2021-11-01
Recent studies have shown that the tumor microenvironment has many mechanisms to act on the tumor microenvironment, including:(1) There are bacterial peptides in cancer cells and immune cells,(2) Bacterial antigens mimic tumor antigens(3) Microbes induce immunogenic cell death(4) Auxiliary pattern recognition receptor-mediated signaling pathway(5) Metabolites derived from microorganisms(6) Stimulus inhibition checkpoint .
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UCSD: Refractory depression, a powerful option for magnetic convulsion therapy
Time of Update: 2021-11-01
Daskalakis, professor of psychiatry and chair of the Department of Psychiatry at the University of San Diego School of Medicine, and senior author , To study whether continuous magnetic convulsion therapy (MST) may effectively prevent the recurrence of TRD, especially compared with known electroconvulsive therapy (ECT), electroconvulsive therapy is the current standard of treatment, but its results are complicated and The history of controversy .
