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The first patient-specific zebrafish model for arrhythmic cardiomyopathy

 Last Update: 2021-12-28
 Source: Internet
 Author: User

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Image: Shows the heart of a healthy wild adult zebrafish and a PLN.

The first patient-specific zebrafish model for arrhythmic cardiomyopathy

The research team of Jeroen Bakkers (Hubrecht Institute/UMC Utrecht) and Toon van Veen (UMC Utrecht) proposed the first patient-specific model for arrhythmic cardiomyopathy (ACM)

Arrhythmic cardiomyopathy (ACM) is a heart disease that causes a layer of fat to accumulate on the outer layer of the heart to replace the healthy heart muscle

Zebrafish model

Researchers from the teams of Jeroen Bakkers (Hubrecht Institute/UMC Utrecht) and Toon van Veen (UMC Utrecht) were able to reproduce the human form of ACM in zebrafish

Rescue cell dysfunction

"Once we know that we can mimic ACM by introducing PLN mutations in zebrafish, we need a way to rescue the cellular changes that subsequently occur in the heart," Sarah, one of the first authors of the journal Nature Communications Carmel explained

The first different model

Since previous animal studies could not reproduce the accumulation of fat in the heart, this zebrafish model provides the first ACM patient-specific model

Further research

Researchers are continuing to study the important mechanisms of the development of this disease

Article Title

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model 2 for phospholamban R14del cardiomyopathy

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