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The common slow poke potassium ion channels in Drosophila are huge and complex proteins located in the cell membrane.
In order to design drugs against pests, scientists need high-resolution ion channel structures
Detailed diagram of the drug discovery potassium channel
A specific position in this channel is called the RCK2 pocket, and its amino acids differ between Drosophila and humans
In addition, the researchers also solved the low-temperature em structure of the channel with two known compounds, verructin and emodepside
Article title
Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM