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During the metastasis of cancer, cancer cells will leave the tumor and spread to other parts of the body
According to the results of the study published in the journal Nature Cancer, these cells secrete type III collagen into their surrounding environment, thereby maintaining a resting state, and only become malignant when the collagen level gradually decreases
Corresponding author, Dr.
"This intervention aimed at preventing the awakening of dormant cells is expected to become a therapeutic strategy to prevent metastatic growth
Most cancer deaths are caused by metastasis, which may occur several years after tumor removal
This research uses high-resolution imaging techniques, including in vivo two-photon microscopy, which allows real-time observation of dormant cells in the environment of living animals
Researchers found that type III collagen is necessary to maintain tumor dormancy, because its destruction can restore tumor cell proliferation through STAT1 signaling
When treating wounds, people are now beginning to use collagen scaffolds to promote the healing of complex wounds
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Di Martino, JS, Nobre, AR, Mondal, C.