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Study on Regulation of Hyperimmune Disease Related Gene CCL17

 Last Update: 2021-12-28
 Source: Internet
 Author: User

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Figure: A group of scientists from the University of Texas recently clarified the complex CCL17/TARC chemokine regulation pathway, revealing insights that can help us design new therapies for immune system-related diseases

Source: https://pixabay.

Allergies and many other types of immune system-related diseases originate from the interaction of complex chemical pathways that affect the behavior, distribution, and development of cells

In order to solve this knowledge gap, a team of scientists from Japan conducted a detailed study.

The team conducted a series of detailed experiments to clarify the relationship between CCL17, pu1 and other related transcription factors and promoters at the molecular level

After using sirna to target PU.

Through further cell culture experiments and computational analysis, the research team found that IRF4 and pu1 work together to activate the transcription of TARC in dendritic cells (copying DNA fragments into RNA) through the regulatory region of the CCL17 gene

Finally, the scientists used an asthmatic mouse as a model to test the effect of pu1 inhibition in vivo

These results highlight the importance of pu1 in inflammatory processes and immune diseases, and may pave the way for new treatments

It is hoped that further research will help to further clarify the regulation and transcription pathways of CCL17, so as to have a more comprehensive understanding of the complex panorama of immune diseases

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