Young people got Parkinson's disease after contracting the new crown!

The scary thing about the new coronavirus is that it not only causes respiratory symptoms, but also affects other tissues and organs

In the journal ACS Chemical Neuroscience under the American Chemical Society, researchers found that the N protein of the new coronavirus can interact with α-synuclein to accelerate the formation of amyloid deposits

Cases of neurodegenerative disease caused by viral infection are not uncommon

For neurodegenerative diseases such as Parkinson's disease, abnormal accumulation of certain proteins is a typical pathological feature

Based on the symptoms of Parkinson's disease in some young people after contracting the new crown, the researchers decided to explore the relationship between the two diseases

In the absence of the new coronavirus, the researchers found that it takes more than 240 hours for α-synuclein to accumulate to form fibrils

What's interesting is that when they added the N protein from the new coronavirus, the speed of deposition formation was greatly accelerated-it only takes less than 24 hours for α-synuclein to accumulate!

▲The effect of new crown S protein (left picture) and N protein (right picture) on the deposition rate of α-synuclein

Further research found that the N protein and α-synuclein of the new coronavirus can be directly combined with each other through different charges! In the model, each N protein can bind at least 3-4 different α-synuclein

In order to confirm the results observed in the test tube, the researchers used a Parkinson's disease cell model for analysis

What is even more exaggerated is that after the simultaneous injection of N protein, the distribution of many α-synuclein proteins has changed, and the structure has also been lengthened, which makes people doubt whether this is amyloid deposition (not yet confirmed)

▲This study found that the new crown N protein can bind to the typical pathological protein of Parkinson’s disease α-synuclein (picture source: reference [2]; Adapted from ACS Chemical Neuroscience 2021, DOI: 10.

The authors pointed out that a major symptom of the new crown we know is that people lose their sense of smell and taste, and the loss of smell and taste is precisely the early symptom of Parkinson's disease

Reference materials:

[1] Slav A.

[2] SARS-CoV-2 protein interacts with Parkinson's protein, promotes amyloid formation, Retrieved December 14, 2021, from https://