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Nature Sub-Journal: Not only exosomes, cells also contain super particles
Time of Update: 2021-12-28
Corresponding author, Professor Robert Coffey of Vanderbilt University Medical Center said: "We have identified multiple biomarkers and therapeutic targets for cancer and other disease states.
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
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Cell Rep: Improved drug choice for patients with colorectal cancer
Time of Update: 2021-12-28
Now, Assistant Professor Salk and internal medicine scientist Edward Stites uses computer modeling and cell research to find that more patients can be helped by a common targeted therapy, which is more than previously thought .
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Second successful pig kidney xenotransplantation
Time of Update: 2021-12-28
Less than two months after the first breakthrough operation, the New York University Langone Health Center performed a second experimental xenotransplantation using genetically engineered pig kidneys .
He transplanted a pig kidney lacking the alpha-galactose gene to a donor who had recently passed away on a ventilator .
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Grouped-seq: a high-throughput analysis platform technology that can simultaneously obtain tumor organoid phenotype and expression profile information
Time of Update: 2021-12-28
On December 10, 2021, the research group of Researcher Liu Peng from the Department of Biomedical Engineering of Tsinghua University School of Medicine and Associate Professor Chen Xiaofang of Beijing
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It is expected to change the treatment model of first-line lymphoma Roche ADC combination reduces the risk of disease progression by 27%
Time of Update: 2021-12-28
On December 14, 2021, Genentech, a Roche subsidiary, announced that the "first-in-class" CD79b-targeted antibody-conjugated drug (ADC) Polivy (polatuzumab vedotin) will be linked to a treatment program called R-CHP It has been used in the first-line treatment of patients with diffuse large B-cell lymphoma (DLBCL) in Phase 3 clinical trials with positive results .
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Nature Cancer: How to keep tumor cells dormant?
Time of Update: 2021-12-28
Researchers found that after adding this collagen to the environment around the cells, they can force the cells to stay dormant and prevent tumor recurrence .
This study shows that increasing the type III collagen in the tumor microenvironment can prevent cancer metastasis by activating tumor cell dormancy .
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Chronic obstructive pulmonary disease: a genetic mutation confirmed as a predisposing factor
Time of Update: 2021-12-28
In this context, scientists from the Paris Pasteur Institute (Université de Paris, CNRS, Inserm, Reims-Champaign-Ardenne), Reims University Hospital (Reims University Hospital) and French Pasteur de Lille Institute (Institut Pasteur de Lille) proved that replacing a single nucleotide in the gene encoding the nicotine acetylcholine receptor can cause changes in the function of airway cells and cause symptoms similar to COPD, independent of smoking .
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How food intake changes the gut
Time of Update: 2021-12-28
Today, by using different mouse models in combination with human intestinal biopsies, they have deciphered the molecular mechanisms that control this surprising organ plasticity and found that increasing the amount of food can improve the absorption surface and function of the intestine .
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Breakthrough success!
Time of Update: 2021-12-28
Image source: The University of Hong KongThe research results will be published in the "Journal of Chemical Engineering" on November 25, 2021, entitled "Anti-pathogen stainless steel combating COVID-19" .
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"Mini brain" provides clues to the origin of early life in schizophrenia
Time of Update: 2021-12-27
According to a new study by Weill Cornell medical researchers, in the first month of embryonic development, multiple changes in brain cells may lead to schizophrenia in the future .
Colak said that she believes that miniature brains grown from patient stem cells may be useful tools for studying other brain diseases .
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Drying and warming climate causes the growth and decline of Cangshan fir in northwestern Yunnan
Time of Update: 2021-12-27
) As the research object, analyzed the climate sensitivity and long-term growth rate change trend of Cangshan fir radial growth, calculated the intrinsic water use efficiency using the stable isotope of tree ring carbon, and applied the dual isotope method ( δ 13 C, δ 18 O) The transition pattern of tree physiological processes (stomatal conductance, photosynthesis) from cold and wet years to warm and dry years was detected.
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Associate Professor Wang Fang and Professor Chen Zilin's research group have made new progress in the detection of nucleic acid special modified base 5-formyluracil
Time of Update: 2021-12-27
986 ) published the College of Pharmacy, Wuhan University Professor Wang Fangfu with Professor Chen Zilin special research group in nucleic acid modified bases 5- formyl uracil (5fU) detection The new results obtained in the field, the title of the paper is "Highly Selective Electrochemical Detection for 5-Formyluracil Relying on (2-Benzimidazolyl) Acetonitrile Labeling" .
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Science Advances discovers key enzymes in plant coenzyme Q synthesis pathway
Time of Update: 2021-12-27
This study identified the hydroxylase CoqF at the benzene ring of the coenzyme Q synthesis pathway in eukaryotic mitochondria, and found that CoqF is widely present in plants, algae, acrocomplexes, Euglena and other groups .
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CLN7 is an organelle chloride channel that regulates lysosome function
Time of Update: 2021-12-27
In addition, CLN7 also regulates lysosomal chloride ion conductance, lumen pH and lysosomal membrane potential, and promotes the release of lysosomal CaTwo+Transient receptor potential mucin 1 (TRPML1) .
Pathogenic mutations in CLN7 lead to reduced chloride ion permeability, suggesting lysosomal Cl reconstitution?Homeostasis may be an effective strategy for the treatment of vLINCL .
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Blood: NK cell-based immunotherapy is effective for patients with relapsed leukemia
Time of Update: 2021-12-27
Louis recently demonstrated in a small clinical trial that natural killer cell-based immunotherapy is effective for some children and young patients with relapsed acute myeloid leukemia (AML) .
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Professor Li Liang’s research group published a paper on Hearing Research, revealing that the envelope and fine structure of sound have different binaural processing modes in the rat’s auditory midbrain
Time of Update: 2021-12-27
Past studies have suggested that the envelope components and fine structure components of binaural information have different contributions to auditory perception .
Different binaural processing of the envelope component and the temporal fine structure component of a narrowband noise in rat inferior colliculus.
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He Xianghuo/Liang Linhui's team "Cell Discovery" reveals a new way for RP11-295G20.2 to induce PTEN degradation
Time of Update: 2021-12-27
2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation" in Cell Discovery , revealing the long Stranded non-coding RNA RP11-295G20.
2 can directly bind to the PTEN protein, and promote its binding to the p62 protein, and degrade it through the autophagy-lysosome pathway .
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Pan-cancer single cell atlas of tumor infiltrating T cells
Time of Update: 2021-12-27
Theoretical basisIn order to establish a high-resolution pan-cancer T cell profile, we performed single-cell RNA sequencing (scRNA-seq) on blood samples from tumors, para-cancerous tissues, and patients with different cancer types, and collected other published scRNA-seq Data set .
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Studies in mice indicate that immune cell subsets may promote inflammation in multiple sclerosis
Time of Update: 2021-12-27
A new study by researchers at Weill Cornell Medical College and New York Presbyterian Hospital in mice shows that a group of immune cells that prevent inflammation of the gastrointestinal tract may be effective against multiple sclerosis (MS) and other brain inflammations.
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The SARS-CoV-2 capsid interacts with Parkinson’s disease protein to promote the formation of amyloid
Time of Update: 2021-12-27
This fact, as well as the case reports of Parkinson's disease in COVID-19 patients, made Christian Blum, Mireille Claessens and others wonder whether the protein component of SARS-CoV-2 can trigger the aggregation of α-synuclein into amyloid .
