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Associate Professor Wang Fang and Professor Chen Zilin's research group have made new progress in the detection of nucleic acid special modified base 5-formyluracil

 Last Update: 2021-12-27
 Source: Internet
 Author: User

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11 Yue 23 Ri, Analytical Chemistry (Analytical Chemistry, Journal of the American Chemical will, IF = 6.

In addition to the five basic bases in nucleic acids , there are many special bases that are naturally modified, such as the methylation modification on cytosine in DNA .

In this paper, a highly selective electrochemical sensing strategy based on 2 -benzimidazolyl acetonitrile label is proposed and successfully applied to the specific detection of 5fU in gDNA .

Figure: Schematic diagram of electrochemical detection of 5fU

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