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The mechanism of praziquantel on ion channels of parasitic flatworms
Time of Update: 2021-12-24
Praziquantel (PZQ) is an important antiparasitic drug for the treatment of parasitic diseases such as schistosomiasis, but its mechanism of action has not yet been elucidated .
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How did Israel become a global leader in life science innovation?
Time of Update: 2021-12-24
Subsequently, local pharmaceutical companies began to carry out intensive innovative research and development activities, and a large number of mergers and acquisitions in Europe and the United States, to further promote the development of Israel's industry .
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Improve the target of solid tumor immunotherapy: transcription factor Blimp1
Time of Update: 2021-12-24
Jianmei LeavenworthIn cancer, the main obstacle of anti-tumor immunity and immunotherapy is the infiltration of regulatory T cells or T-reg cells into tumors .
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Neuron: This protein in the brain may be a biomarker of autism
Time of Update: 2021-12-24
The results of this research titled "Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2" were published in "Neuron" magazine .
###Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2DOI: https://doi.
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Professor Jiang Ying’s research group from the Quantum Materials Science Center of the School of Physics was invited to publish in the "Surface Science Report" a review of the use of high-resolution atomic force microscopy to detect the water-solid interface
Time of Update: 2021-12-24
On November 20, 2021, Professor Jiang Ying’s research group from the Quantum Materials Science Center of Peking University School of Physics and Director of the Light Element Advanced Materials Research Center was invited to write a review "Using high-resolution atomic force microscopy to detect water-solid interfaces" ( Water-solid interfaces).
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Mice are not a "universal model" for vertebrate development
Time of Update: 2021-12-24
"This is the first example of a mutation in a vertebrate causing an obvious positional change in the identity of a tooth," said Lotta Salomies, a PhD researcher at the HiLIFE Institute of Biotechnology at the University of Helsinki .
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An exciting tool to "see" the connections of millions of cells in the mouse brain
Time of Update: 2021-12-24
The researchers said that this new tool provides an unprecedented perspective to observe brain cell activity in synapses .
In this study, the scientists inserted the GRIA1 gene into the DNA of mice to produce green light-emitting tags on all AMPA glutamate proteins .
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PNAS's newly discovered inflammatory mediator stimulates tissue regeneration and controls granuloma formation
Time of Update: 2021-12-24
The biosynthetic product cysteine isomers discovered by the team can accelerate the tissue regeneration of planarians injured by surgery and inhibit the development of granulomas in human peripheral blood leukocytes .
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Significantly lower pulmonary artery pressure in patients with nitric oxide therapy phase 2 trial results are positive
Time of Update: 2021-12-24
A few days ago, Bellerophon Therapeutics announced that a dose-escalation phase 2 clinical trial of inhaled nitric oxide therapy INOpulse has achieved positive results .
Reference materials:[1] Bellerophon Reports Positive Top-Line Data from Phase 2 Acute Dose Escalation Study of INOpulse® for Treatment of Pulmonary Hypertension Associated with Sarcoidosis.
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Eli Lilly’s Phase 3 Eczema Therapy Trial Reports Good News Again, Plans to Submit Regulatory Applications Next Year
Time of Update: 2021-12-24
On December 21, 2021, Eli Lilly and Company announced that it is the third critical phase 3 of the investigational IL-13 inhibitor lebrikizumab combined with topical corticosteroids (TCS) for the treatment of patients with moderate to severe atopic dermatitis The clinical trial, which reached all its primary and key secondary endpoints at week 16, proved that the lebrikizumab combination therapy group can significantly improve the severity of the patient’s disease .
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Improve short-read sequencing genome reference bias Giraffe pan-genome mapping tool improves structural variation recognition
Time of Update: 2021-12-24
"In this new study, the researchers used publicly available genome data to construct two reference maps of the human genome to evaluate the new tool Giraffe .
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Sequencing costs for bacterial genomes dropped to $10, helping to cope with global pandemics
Time of Update: 2021-12-24
He added: “For low- and middle-income countries, the adoption of large-scale genome sequencing and bacterial pathogen analysis will be a huge public health and surveillance asset .
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A new muscle layer was found on the chin
Time of Update: 2021-12-24
In the previous edition of Gray's Anatomy, published in 1995, the editors also described the masseter muscle as having three layers, although the research cited was based on the mandibular muscle tissue of other species, and to a certain extent Contradictory .
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Loss of ATF4 leads to functional senescence-like wear and tear of adult hematopoietic stem cells
Time of Update: 2021-12-24
Here, we report that ATF4 deficiency causes severe HSC defects and various aging-like phenotypes through cell-autonomous mechanisms .
Mechanically,ATF4Deficiency can damage HSC function, has an aging-like phenotype, and reduces the occurrence of leukemia by regulating HIF1α and p16Ink4a.
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If genes related to autism are missing, it will lead to a decrease in myelin
Time of Update: 2021-12-24
A new study found that in mice with missing genes related to autism spectrum disorders, myelin (an insulating sheath that surrounds nerves that allows electrical impulses to effectively propagate through the central nervous system) is reduced .
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Moderna released the latest data on mRNA vaccines: the level of neutralizing antibodies in the booster needle increased by 83 times
Time of Update: 2021-12-24
Article source: Medical Rubik's Cube InfoAuthor: Shi BeiOn December 20, Moderna announced the preliminary neutralizing antibody data of the mRNA new crown vaccine (elasomeran, mRNA-1273) at 50 µg and 100 µg doses against the Omicron variant .
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A biological paradox provides new insights into the mystery of cancer
Time of Update: 2021-12-24
Its purpose is to assess the species-specific cancer mortality of various mammals, re-examine the claims of Pitto's paradox in a rigorous and quantitative manner, and explore possible cancer suppression mechanisms related to humans and animals fighting diseases .
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Cell Rep: Functional dependence between key intermediary genes of different tumors
Time of Update: 2021-12-24
In a new study published today in Cell Reports, the research team used a network model to study a series of interactions that are critical to malignant tumors, which may be fertile ground for a wide range of cancer treatments .
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2021 International Conference on Cancer and Aging and the Fifth Doctoral Forum
Time of Update: 2021-12-24
Chinese Chairman Liu Jianfeng, Professor of Huazhong University of Science and Technology, French Chairman, Prevost Gregoire, President of CIPREVO, France, and Professor Sylvain Fisson, representative of Évry University in France, then welcomed the experts, scholars and students participating in the conference and kicked off the conference .
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The small mammal adaptive evolution and management discipline group has made new progress in the study of the composition and function of the intestinal flora of plateau pikas in response to swainsonine compounds
Time of Update: 2021-12-24
The results of the study showed that indoor breeding significantly reduced the alpha diversity of the intestinal flora of plateau pikas, and had a significant impact on beta diversity and function, as well as the abundance of core flora .
