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The bearded lizard (Pogona vitticeps) shows its teeth
Helsinki University Laboratory
Researchers at the HiLIFE Institute of Biotechnology at the University of Helsinki compared two pogona vitticeps: one is normal and the other is a mutant without body scales
"This is the first example of a mutation in a vertebrate causing an obvious positional change in the identity of a tooth," said Lotta Salomies, a PhD researcher at the HiLIFE Institute of Biotechnology at the University of Helsinki
The gene affected by mutations in lizards was previously identified as ectodysplastic protein A (EDA)
The effect of changes in the expression of a single gene further confirms that the fine-tuning of the gene network during tooth development is very important
In addition, this simple mechanism is likely to produce the large variability of dentition observed in non-mammalian lineages
The general mechanism of tooth development has been extensively studied through a classic research model-mice
"For example, the teeth of mice are not replaced during the life of the animal, but most other vertebrates have two or more sets of teeth
10.
