-
Twist Bioscience is now selling a synthetic RNA positive control for the new crown mutant strain Omi Keron (B.1.1.529/BA.1) in order to develop accurate diagnostic tests
Time of Update: 2021-12-24
South San Francisco, California, USA--(Business Wire)--December 15, 2021--Twist Bioscience (NASDAQ: TWST) is a company that uses its silicon-based platform to provide high-quality synthetic DNA to help customers obtain A successful company, the company today announced the launch of a synthetic RNA positive control for the SARS-CoV-2 mutant strain Omi Keron (B.
-
Researchers describe a mechanism that destroys cancer cell proliferation and causes death
Time of Update: 2021-12-24
Researchers at UAB and Vall d'hebron discovered the mechanism by which ERK5 protein kinase inhibitors weaken the proliferation of cancer cells and induce their death .
-
Newly discovered gut-derived metabolites play a role in neurodegeneration
Time of Update: 2021-12-24
A multi-institutional research team in New York found that the cerebrospinal fluid and plasma samples of patients with multiple sclerosis (MS) contained high levels of three toxic metabolites produced by gut bacteria .
-
The first!
Time of Update: 2021-12-24
The drug has been approved by the US FDA for 3 indications-treatment of moderate to severe plaque psoriasis suitable for phototherapy or systemic therapy; adult patients with active psoriatic arthritis; and Behcet's disease related Adult patients with oral ulcers .
Reference materials:[1] FDA Approves Otezla (Apremilast) For The Treatment Of Adult Patients With Plaque Psoriasis, Regardless Of Severity Level.
-
JAMA Sub-Journal: The sharp drop in lung cancer mortality is related to early CT screening
Time of Update: 2021-12-24
Researchers from the Mount Sinai Medical System found that the recent sharp drop in lung cancer mortality is related to the early diagnosis of lung cancer, which indicates the need to strengthen screening to save lives .
-
Specificity of Gβγ subunits of the decoy complex before and after stimulation of α2a adrenergic receptors
Time of Update: 2021-12-24
This analysis reveals the neuron-specific and GPCR-dependent changes of Gβγ dimers that interact with trap proteins, and provides molecular details for the regulation of synaptic transmission .
-
Bluebird bio-gene therapy lovo-cel was once again clinically shelved by the U.S. FDA
Time of Update: 2021-12-24
On Monday, Bluebird Bio issued an announcement stating that the FDA has partially shelved the clinical study of lootibeglogene autotemcel (lovo-cel, bb1111) for the treatment of sickle cell disease (SCD) patients under 18 years of age .
-
How does Wolbachia make mosquitoes "infertile"?
Time of Update: 2021-12-24
This work has laid the foundation for understanding CI at the molecular level, and is of great significance to the use of Wolbachia and CI to prevent and control mosquito-borne diseases and agricultural pests .
-
Studies have found that reducing frailty can reduce the incidence of dementia
Time of Update: 2021-12-24
The study, published in the Journal of Neurology, Neurosurgery, and Psychiatry, found that weakness is an important risk factor for dementia, even for people with a high genetic risk of dementia.
-
Use photoacoustic imaging to observe the body in depth
Time of Update: 2021-12-24
The researchers used a contrast agent based on surfactant-stripped semiconducting polymer (SSS) micelles and a 1064 nm laser to successfully demonstrate the in vivo imaging depth of the rat’s intestines and bladder up to 5.
-
Reduce the common delirium local anesthesia or general anesthesia after surgery?
Time of Update: 2021-12-24
The study found that compared with general anesthesia, the use of local anesthesia without sedation for hip fracture surgery patients ≥65 years of age did not significantly reduce the incidence of postoperative delirium .
-
Nature: How neuronal diversity is produced
Time of Update: 2021-12-24
They are particularly interested in whether different types of cells can be derived from a single progenitor cell, and at which point in the development process determines the fate of neurons .
Therefore, one progenitor cell can produce different types of neuronal cells until late in development .
-
Cell Stem Cell challenges the traditional view: some genes have been turned on from the very beginning
Time of Update: 2021-12-24
The research team used a method called RNA sequencing to accurately analyze individual human eggs and single-cell embryos, detailing signs of gene activity, that is, RNA transcripts .
-
How to exercise regularly to prevent fatty liver related diseases
Time of Update: 2021-12-24
Exercise prevents fatty liver by changing the compensatory response of mitochondrial metabolism to accommodate excessive substrate availability .
A new study by the German Diabetes Research Center (DZD), Helmholtz Munich and Tübingen University Hospital shows that molecular adaptations can be observed in this process, especially liver mitochondria .
-
New discovery: "Photosynthesis" algae can survive in the dark
Time of Update: 2021-12-24
"This is very important for the distribution of carbon dioxide on the earth," Balch said .
This new study reveals that algae also absorb carbon from previously undiscovered sources deep in the water column .
Osmotrophy of dissolved organic carbon by coccolithophores in darkness .
-
Bring the cells closer together to form new tissues
Time of Update: 2021-12-24
When cells are cultured on this biological material, the molecular mobility of polyrotaxane can affect cell-cell adhesion through one of its main players, a protein called yes-associated protein (YAP) .
Therefore, we hypothesized that YAP can enhance the cell-cell adhesion of epithelial cells by affecting the molecular mobility on the polyrotaxane surface .
-
Induction of IL19 expression through JNK and cGAS STING to regulate DNA damage-induced cytokine production
Time of Update: 2021-12-24
Stress produces cytokinesDNA damage, such as damage caused by ionizing radiation or inhibition of DNA replication checkpoint kinases, activates the cGAS-STING pathway and the transcription factor NF-κB, thereby triggering the secretion of pro-inflammatory cytokines, such as IL-1, IL-6 and IL- 8 .
-
Genetic analysis of praziquantel response in schistosoma parasites shows the existence of transient receptor potential channels
Time of Update: 2021-12-24
Identification of TRPM using genome-wide association screening and marker-assisted selectionPZQ CompanyResponsible for changes in PZQ sensitivity and check sequence changes in TRPMPZQ CompanyIsolated from the wild .
TRPM CorporationPZQ CompanyThe difference in PZQ response between PZQ-enriched resistance (PZQ-ER) and PZQ-enriched sensitive (PZQ-ES) parasite populations was greater than 377 times .
-
Key genes for longevity: Scientists have created an age-related gene network
Time of Update: 2021-12-24
Researchers from the Babraham Institute’s Epigenetics Research Project published a map of Caenorhabditis elegans gene interactions in the journal Science, which can be used to identify new genes that affect lifespan and have the same genes in humans New genes .
Together, they created the largest gene regulatory interaction network found in a long-lived Caenorhabditis elegans .
-
New function of the old protein: tBID can directly trigger cell death
Time of Update: 2021-12-24
" Garcia-Saez said: "For example, when other known apoptosis signaling pathways fail or lack the protein that executes it, activation of tBID may induce cell apoptosis.
In Shigella infections, proteins that normally induce apoptosis are not activated .
