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In patients with autism, the incidence of epilepsy is also quite high, usually in infancy and adolescence
They recently discovered a key brain protein that can calm overactive brain cells and is at an abnormally low level in children with autism
The results of this research titled "Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2" were published in "Neuron" magazine
The researchers pointed out that although many neuronal membrane proteins undergo proteolysis, the biological significance of neuronal extracellular domain shedding (ES) is still poorly understood
They analyzed the cerebrospinal fluid of patients with autism and epilepsy, as well as the cerebrospinal fluid of mouse models
Corresponding author, Dr.
"Our data emphasizes the prospects of shedding group analysis in studying neurobiological mechanisms.
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Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
DOI: https://doi.