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    Home > Biochemistry News > Biotechnology News > Pan-cancer single cell atlas of tumor infiltrating T cells

    Pan-cancer single cell atlas of tumor infiltrating T cells

    • Last Update: 2021-12-27
    • Source: Internet
    • Author: User
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    Cancer-related T cell atlas

    There are many different types of immune cells in the tumor microenvironment, the composition, function and role of which are still unclear


    Using single-cell RNA sequencing technology to sequence the T cells of 21 cancer types from more than 300 patientsWait.


    Tumor infiltrating T cells often enter a dysfunctional state, that is, T cell failure.


    After correcting for confounding factors and batch effects, integrate different data


    The status of pTRTs in the tumor microenvironment of different tumor types is very different


    The systematic comparison of different cancer types reveals the commonalities and differences of T cell states in different tme


    T cells play an important role in tumor immunotherapy, but we lack a systematic comparison of the heterogeneity and dynamics of tumor infiltrating T cells


    We have established a single-cell RNA sequencing profile of T cells from 316 donors for 21 cancer types, revealing different patterns of T cell composition


     

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