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Researchers at Washington University School of Medicine in St.
The Phase I clinical trial included a total of 8 patients, ranging in age from 1 to 30 years old
The first author and Assistant Professor of Pediatrics, Dr.
Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow that causes the overproduction of immature white blood cells, which crowd out healthy blood cells
Of the eight patients who received the experimental treatment, four patients had a complete remission on the 28th day after treatment
For the other four patients, two patients partially responded to the treatment, and their disease symptoms were reduced, but they did not enter the remission period
Dr.
Natural killer (NK) cells are a type of immune cells that attack foreign or damaged cells, including bacteria or virus-infected cells and even cancer cells
The researchers collected NK cells from donors and then exposed them to three cytokines (IL-12, IL-15, and IL-18) in the laboratory
Senior author Professor Todd A.
Based on the experience of these eight patients, the researchers are making some modifications to the treatment plan in order to be more effective for future patients
Professor Fehniger said: “We plan to use this method in a larger cohort of children and adults
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Bednarski JJ, et al.
