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Cell: Looking at the evolution of complex organs from the unique skills of the paederus
Time of Update: 2021-12-29
Corresponding author Joseph Parker of the California Institute of Technology said: "We are very interested in how the paederus pieced together these glands in the abdomen, because these structures are composed of different cell types .
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Relieving greed and losing weight: After eating for 14 days, the white fat turned brown!
Time of Update: 2021-12-29
In a new study published in the journal Nutrients , a team led by Professor Naomi Osakabe of the Graduate School of Engineering and Science at Shibaura Institute of Technology in Japan demonstrated that FLs promote the browning of adipose tissue by activating SNS .
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Nature: The first detailed image of ALS-related molecules opens the door to treatment
Time of Update: 2021-12-28
Scientists at the Molecular Biology Laboratory of the Medical Research Council (MRC) in Cambridge, UK, who led the study, said the discovery may enable the targeted development of new medical interventions and diagnostic tests .
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Scientists have discovered a new gene that controls the left and right asymmetry of the human body
Time of Update: 2021-12-28
Co-corresponding author, Professor Bruno Reversade of the Human Genetics and Therapeutics Laboratory of the Singapore Genome Research Institute, said: "Our phylogenetic screening of genes that have disappeared in vertebrates provides important evolutionary insights into the development of the left and right patterns .
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The Lei Xiaoguang research group of the School of Chemistry and collaborators discovered the first exo-selective intermolecular Diels-Alder reaction enzyme in nature
Time of Update: 2021-12-28
Words for Java 18. 9" >Pharmaceutical intermediates, pesticides and fine chemicals occupy an important position in the national economy and people's livelihood . Traditional chemical synthesis proce
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New hope for patients with relapsed large b-cell lymphoma
Time of Update: 2021-12-28
"Improve treatment with new drugsFor the past four years, Kamdar has been the lead investigator of a global, multi-center, phase III clinical study, which aims to find out that Breyanzi (lisocabtagene maraleucel; Liso-cel) can improve the performance of these patients.
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Multi-level green barrier disinfection system blocks the "material transmission" of the new coronavirus
Time of Update: 2021-12-28
In order to effectively cut off the "material-to-person" transmission of the new coronavirus through cold chain logistics, the Ma Jun team proposed a multi-level green barrier disinfection system that covers the entire life cycle of cold chain goods .
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Xu Lin's research group answers "Why callus can regenerate organs"
Time of Update: 2021-12-28
On November 15, 2021, the Xu Lin research group of the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences published a cover article "Pluripotency acquisition in the middle cell layer of callus is required for organ regeneration" in Nature Plants , revealing from the single cell and molecular level The mechanism by which callus has the ability to regenerate organs .
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Nature Sub-Journal: Your DNA will determine when you have sex for the first time and when you become a parent
Time of Update: 2021-12-28
Later, by using genome-wide association analysis (GWAS), they found autosomal single nucleotide polymorphisms (SNPs) sites, which, together with our environmental factors, affect two milestones in people’s lives ——The age of first sex and the age of parenting for the first time!
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Wang Jiawei's research team reveals the essential reason for the irreversibility of plant age
Time of Update: 2021-12-28
On November 9, 2021, the international academic journal PNAS published an online study titled "Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis " from the Wang Jiawei research group of the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences .
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It was discovered for the first time that whether the immune system can form high-quality antibodies depends on this enzyme
Time of Update: 2021-12-28
When healthy mice are infected with the mosquito-borne parasite malaria, TBK1 reduces the activity of genes that prevent B cell development, allowing them to grow into mature memory B cells .
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Ten years of grinding a sword, Professor Li Hongliang's team develops a new treatment for non-alcoholic steatohepatitis
Time of Update: 2021-12-28
On December 15, 2021, Professor Li Hongliang’s team published two articles titled "Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis" and "A small molecule targeting ALOX12" in the top international journal Science Translational Medicine.
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Anti-aging!
Time of Update: 2021-12-28
In mouse experiments, the researchers found that NOX4 in the skeletal muscle increases after exercise, which in turn leads to an increase in ROS, which triggers an adaptive response and protects mice from the development of insulin resistance, which is induced by aging or diet Of obesity .
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CAR-T therapy is moving to the front line!
Time of Update: 2021-12-28
According to a Gilead press release, in the ZUMA-1 study, the five-year overall survival (OS) rate of patients after a single infusion of Yescarta was 42.
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All-plant medical marijuana in the treatment of severe and refractory epilepsy in childhood
Time of Update: 2021-12-28
In view of this, the researchers evaluated the use of whole plant medicinal cannabis in 10 children with severe epilepsy who did not respond to conventional treatment.
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Chromatin structure of susceptible gene sites in Purkinje cells of the cerebellum to characterize neurodegeneration induced by DNA damage
Time of Update: 2021-12-28
We found that neurodegeneration and ataxia are caused by transcriptional interference in the cerebellum through abnormal messenger RNA splicing .
These data reveal the pathogenic basis of DNA damage in the nervous system and suggest that chromatin conformation is a feature that guides neuropathology related to genome instability .
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Study on Regulation of Hyperimmune Disease Related Gene CCL17
Time of Update: 2021-12-28
Figure: A group of scientists from the University of Texas recently clarified the complex CCL17/TARC chemokine regulation pathway, revealing insights that can help us design new therapies for immune system-related diseases .
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Abnormal Ca2+ signaling of IP3R in adipocytes is related to inflammation and metabolic disorders in obesity
Time of Update: 2021-12-28
Inflammation caused by obesity in vitro or in vivo can lead to increased abundance and activity of IPthreePhosphorylation of Rs and CaTwo+-The dependent kinase CaMKII in adipocytes is dependent on the kinase JNK .
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Lang Zhaobo's research group developed an efficient dicot adenine single-base editor
Time of Update: 2021-12-28
In addition, the researchers have also expanded the Cas9 variant system of the single-base editor driven by pSlEF1α , which can also achieve precise editing of some NG PAM sites in dicotyledonous plants such as Arabidopsis, tomato, and soybean .
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Scientists use ostrich egg antibodies to develop new crown masks
Time of Update: 2021-12-28
Science and Technology Daily, Beijing, December 14 (Intern reporter Zhang Jiaxin) According to recent news from Japan’s "Japan Times" and British "Daily Mail", the development team chaired by Yasuhiro Tsukamoto, president of Kyoto Prefecture University in Japan, used antibodies extracted from ostrich eggs to develop A mask to detect the new crown virus has been developed .
