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The new crown drug "Dipyridamole" screened by Tianhe supercomputer has significant initial clinical effects!
Time of Update: 2021-12-29
By using the ultra-large-scale computing power of Tianhe's new-generation supercomputer, using the internationally leading drug-target combination accurate evaluation calculation method, the rapid screening and discovery of new crown emergency drugs (effectively reducing the fatality rate and severe disease rate) has been realized .
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More than 80% of patients' tumors have shrunk!
Time of Update: 2021-12-29
Article source: Medical Rubik's Cube InfoAuthor: Shi BeiOn December 10, Infinity announced at the San Antonio Breast Cancer Symposium (SABCS) that the PI3Kγ inhibitor eganelisib combined with Atelizumab (Tecentriq) and Albumin Paclitaxel (Abraxane) as the first-line treatment of metastatic triple-negative breast cancer (TNBC) Updated data for the Phase II MARIO-3 study .
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Zhang Hang's research group and collaborators found that free recall reduces inter-item interference during working memory retrieval
Time of Update: 2021-12-29
On April 23, 2021, " Cognition " published an article titled "Free-recall benefit, inhomogeneity and between-item interference in working memory" by Zhang Hang's research group and collaborators at Pe
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The missing gene switch at the origin of the malformation
Time of Update: 2021-12-29
A research team from the University of Geneva (UNIGE) in Switzerland studied the Pitx1 gene, one of the genes involved in the structure of the lower limbs, and discovered how a small disturbance in the activation of this gene is the origin of the deformed foot (a common foot deformity) .
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"NEJM" Three-year clinical trials in patients prove that gene therapy can reverse sickle cell disease
Time of Update: 2021-12-29
Four patients from New York Presbyterian Hospital/Columbia University Irvine Medical Center participated in this multicenter study, which is the first report of long-term results of sickle cell gene therapy .
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The new coronavirus Omicron variant may have "significant" ability to evade vaccine protection-even the third dose of vaccine
Time of Update: 2021-12-29
The findings published in the journal "Emerging Microorganisms and Infections" also show that although the third-dose enhancement strategy can "significantly improve immunity", the protection of omega clones "may be impaired"-but more research is needed To understand this better .
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Researcher Yao Xiang’s research group published new results in the Journal of Vocational Behavior and found that the similarity between the mentor and the mentee promotes the occurrence of information sharing behaviors
Time of Update: 2021-12-29
The latest research results published by Yao Xiang's research group in the Journal of Vocational Behavior show that the similarity between the mentor and the new employee promotes the effectiveness of the relationship between the two and improves the organizational adaptation results of the new employee .
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What are the clinical results of the mRNA vaccine to prevent influenza Moderna?
Time of Update: 2021-12-29
On December 10, 2021, Moderna announced that its Phase 1 clinical trial of the influenza vaccine mRNA-1010 has obtained positive interim data .
"Reference materials:[1] Moderna Announces Positive Interim Phase 1 Data for mRNA Flu Vaccine and Provides Program Update.
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Nature Medicine solves the mystery of obsessive-compulsive disorder
Time of Update: 2021-12-29
In this study, Goodman's team recruited five patients with severe obsessive-compulsive disorder who were eligible for DBS treatment .
Goodman said: "In addition to advancing the treatment of severe obstinate obsessive-compulsive disorder with DBS, this research may improve our understanding of the underlying neural circuits of this disease .
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Guangzhou Health Center achieves targeted differentiation and regeneration of pluripotent stem cells B immune lineage
Time of Update: 2021-12-29
On December 10, Wang Jinyong's research group from Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research paper entitled Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors in Cellular & Molecular Immunology .
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The dawn of a kind of autism gene carrier-early gene therapy
Time of Update: 2021-12-29
"Our work shows the beneficial effects of reactivating the Fmr1 gene, which will be very welcome news for young children living in an FXS environment," said Iryna M.
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The Institute of Zoology collaborates to reveal the mechanism of lung injury in elderly patients with new coronary pneumonia
Time of Update: 2021-12-29
Through detailed analysis of lung lesions and their heterogeneity in patients with COVID-19, the researchers found that two types of epithelial cells of the lung have fallen off and increased apoptosis, inflammatory damage and excessive immune response, changes in different vascular endothelial cells, and blood coagulation function Disorders and events such as cell phenotypic transformation and exacerbation of pulmonary fibrosis are the key damage process and molecular characteristics of COVID-19 lung pathology .
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First-line treatment of lung cancer TIGIT antibody immune combination therapy reduces the risk of disease progression by 38%
Time of Update: 2021-12-29
On December 10, 2021, Genentech, a Roche subsidiary, announced that the new cancer immunotherapy tiragolumab targeting TIGIT, combined with the PD-L1 inhibitor atezolizumab, will be the first-line treatment for PD- Positive results were obtained in Phase 2 clinical trials in patients with L1-positive metastatic non-small cell lung cancer (NSCLC) .
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"PNAS" "Sanctuary" for unknown pathogens in human tissues
Time of Update: 2021-12-29
A research team at the University of Basel has now discovered why some bacteria can survive antibiotic treatment .
Scientists have discovered that antibiotics alone cannot eradicate Salmonella in tissues, but require the help of the immune system to eliminate all bacteria .
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FDA approves new compound therapy Entadfi for common diseases in middle-aged and elderly men
Time of Update: 2021-12-29
On December 13, 2021, Veru announced that the US FDA has approved Entadfi for the treatment of urinary tract symptoms caused by benign prostatic hyperplasia (BPH) .
Reference materials:[1] Veru Announces FDA Approval of Entadfi, a New Treatment for Benign Prostatic Hyperplasia.
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Regal Pharmaceuticals and Eli Lilly have reached a strategic cooperation to jointly research and develop innovative therapies for metabolic diseases
Time of Update: 2021-12-29
"In just over three years, Rieger Pharmaceuticals has developed into a world-class biomedical innovation company with an independent AI-assisted new drug research and development platform CARD (Computer Accelerated Rational Discovery) .
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Professor Zuo Zhenghong's group reveals a new mechanism of endocrine disruptors inducing polycystic ovary syndrome
Time of Update: 2021-12-29
Recently, the research team of Professor Zuo Zhenghong and Associate Professor He Chengyong from the School of Life Sciences of Xiamen University published a paper on " Theranostics " and found that the destruction of TZP would affect the development of follicles, leading to the occurrence and development of polycystic ovary syndrome .
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PNAS: Detect early lung cancer in a drop of blood
Time of Update: 2021-12-29
The researchers first trained their statistical model to identify lung cancer by measuring the metabolomics feature values in blood samples from patients at diagnosis and comparing them with blood samples from healthy controls .
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Chinese scholars have made progress in the regulation mechanism of plant hypoxia signal transduction
Time of Update: 2021-12-29
Figure 1 The molecular mechanism of phosphatidic acid PA regulating plant hypoxia signal transduction. (A) Lipidomics reveals that flooding hypoxia treatment significantly induces PA acc
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Two new methods can simultaneously CRISPR editing of genes in multiple cell types
Time of Update: 2021-12-29
In order to successfully edit the genes of multiple members of a microbial community, scientists at the University of California, Berkeley must develop two new methods: Environmental Transformation Sequencing (ET-Seq), which allows them to evaluate the editability of specific microorganisms; And DNA-editing all-in-one RNA-guided CRISPR-Cas transposase (DART), which allows highly specific targeted DNA to be inserted into the genome location determined by the guide RNA .
