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    Home > Biochemistry News > Biotechnology News > "PNAS" "Sanctuary" for unknown pathogens in human tissues

    "PNAS" "Sanctuary" for unknown pathogens in human tissues

    • Last Update: 2021-12-29
    • Source: Internet
    • Author: User
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    Salmonella survives in the white pulp (red) of the spleen after antibiotic treatment


    Source: Basel University Biology Center

    Antibiotics treat many bacterial infections


    Infections such as tuberculosis or typhoid fever are caused by bacteria and can usually be treated well with antibiotics, at least if the bacteria are not resistant


    The team of Professor Dirk Bumann of the University of Basel’s Biological Center has now shown that this is not due to dormant and therefore insensitive pathogens, as one might expect


    Biopsy tissue

    The head of the study, Bumann, said: "After antibiotic treatment, only about 100 bacteria survived


    To accomplish this Sisyphus-like task, the researchers used so-called serial two-photon tomography, which was previously used in neurobiology to detect the finest nerve fibers in the brain


    Hidden in the police headquarters

    In their study, the researchers imaged the spleens of infected mice


    Antibiotics alone are not enough

    How did these bacteria survive in this surprising place? Scientists have discovered that antibiotics alone cannot eradicate Salmonella in tissues, but require the help of the immune system to eliminate all bacteria


    In order to overcome this problem, the research team tried to improve the body's defense capabilities by simultaneously applying immunotherapy


    In fact, this adjuvant treatment may lead to more effective removal of bacteria and open up new ways to prevent recurrence


    Proceedings of the National Academy of Sciences

    DOI

    10.



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