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Antibiotics treat many bacterial infections
Infections such as tuberculosis or typhoid fever are caused by bacteria and can usually be treated well with antibiotics, at least if the bacteria are not resistant
The team of Professor Dirk Bumann of the University of Basel’s Biological Center has now shown that this is not due to dormant and therefore insensitive pathogens, as one might expect
Biopsy tissue
The head of the study, Bumann, said: "After antibiotic treatment, only about 100 bacteria survived
To accomplish this Sisyphus-like task, the researchers used so-called serial two-photon tomography, which was previously used in neurobiology to detect the finest nerve fibers in the brain
Hidden in the police headquarters
In their study, the researchers imaged the spleens of infected mice
Antibiotics alone are not enough
How did these bacteria survive in this surprising place? Scientists have discovered that antibiotics alone cannot eradicate Salmonella in tissues, but require the help of the immune system to eliminate all bacteria
In order to overcome this problem, the research team tried to improve the body's defense capabilities by simultaneously applying immunotherapy
In fact, this adjuvant treatment may lead to more effective removal of bacteria and open up new ways to prevent recurrence
Proceedings of the National Academy of Sciences
DOI
10.