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The role of gene switches in developmental disorders is largely underestimated
Embryo development follows delicate stages: in order for everything to go smoothly, many genes must coordinate their activities according to a very detailed plan and rhythm
During embryonic development, hundreds of genes must be precisely activated or inhibited in order for organs to develop normally
Guillaume Andrey, a professor in the Department of Genetics and Developmental Medicine at the University School of Medicine who led the research, explained that without this, genes would continue to be turned on or off, so they would not be able to selectively function at the right time and at the right place
Generally speaking, each gene has several switches to ensure that the mechanism is robust
Lead to reduced cell activation of the deformed foot
To do this, the scientists modified mouse stem cells using the genetic engineering tool CRISPR-CAS9
Normally, about 90% of the cells on the leg will activate the Pitx1 gene in the future, while 10% will not
Many genes have the same mechanism
In addition to the Pitx1 gene and varus, scientists at UNIGE also discovered a general principle, and its mechanism can be found in a large number of genes
Nature Communications
DOI
10.
