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The new coronary pneumonia (COVID-19) caused by the new type of coronavirus (SARS-CoV-2) has caused a global outbreak and has seriously endangered human life and health
December 8, 2021, research by Liu Guanghui and Qu Jing research group, Institute of Zoology, Chinese Academy of Sciences, Bian Xiuwu research group, First Affiliated Hospital (Southwest Hospital) of the Army Military Medical University (Third Military Medical University), and Zhang Weiqi, Beijing Institute of Genomics, Chinese Academy of Sciences The group cooperated and published a research paper entitled "A single-cell transcriptomic landscape of the lungs of patients with COVID-19" online in Nature Cell Biology
Through detailed analysis of lung lesions and their heterogeneity in patients with COVID-19, the researchers found that two types of epithelial cells of the lung have fallen off and increased apoptosis, inflammatory damage and excessive immune response, changes in different vascular endothelial cells, and blood coagulation function Disorders and events such as cell phenotypic transformation and exacerbation of pulmonary fibrosis are the key damage process and molecular characteristics of COVID-19 lung pathology
For lung epithelial cells, studies have found that SARS-CoV-2 infection leads to epithelial cell apoptosis and dysfunction, which is mainly manifested as decreased pulmonary surfactant and increased mucus secretion, which may be related to gas exchange disorders and pulmonary hypoxemia Closely related
The study reported a multidimensional omics panorama of the lung tissues of COVID-19 patients, systematically analyzed the disease changes of multiple cell types in the lung tissues of COVID-19 patients, and deepened people's understanding of the multiple structural lesions of the lung tissues of COVID-19 patients And understanding of functional impairment
The relevant data has been uploaded to the Aging Atlas ( https://bigd.
The research was conducted by the Institute of Zoology, Chinese Academy of Sciences, the First Affiliated Hospital of Army Military Medical University (Third Military Medical University), Xuanwu Hospital of Capital Medical University, Beijing Institute of Genomics, Chinese Academy of Sciences (National Center for Bioinformatics), and Institute of Geriatrics, Chinese Academy of Medical Sciences, etc.
Article link: https:// align="center">
Attached figure: The schematic diagram shows that the study revealed that epithelial cell senescence, shedding, elevated apoptosis, excessive inflammation, coagulation and fibrosis intensified are the main pathological phenotypic features of COVID-19 lung, and it is also the origin of systemic immune damage Land" and "main battlefield"
