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    Home > Biochemistry News > Biotechnology News > Zebrafish Whole Brain Transcriptional Atlas Reveals Molecular Regulation Rules of Neuronal Phenotype

    Zebrafish Whole Brain Transcriptional Atlas Reveals Molecular Regulation Rules of Neuronal Phenotype

    • Last Update: 2021-12-28
    • Source: Internet
    • Author: User
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    Brain neurons are highly diverse


    In this study, researchers from the Center for Excellence in Brain Intelligence of the Chinese Academy of Sciences completed single-cell sequencing of the whole brain, brain region specificity, specific neuromodulator / neurotransmitter neurons of the juvenile zebrafish, and mapped the juvenile zebrafish.


    The communication between neurons is mainly through neurotransmitters and neuromodulators


    More interestingly, the researchers found that some transcription factors are very similar cell populations, differences in gene expression effect is great , and even showed a completely different type of neurotransmitter, showing a "divergent" control mode( " Divergent " pattern , Figure 1E )


     

    Figure 1.


    This work uses whole-brain single-cell sequencing analysis to depict the diversity of neurotransmitters and neuromodulators on a whole-brain scale; in addition, it also reveals that transcription factors and post-transcriptional regulatory factors encode molecules of different neuron types.


    Doctoral student Zhang Hui of the Center for Excellence in Brain Science and Intelligent Technology of the Chinese Academy of Sciences, staff Wang Haifang and Xiaoyu Shen are the co-first authors of the paper.


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