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Stroke: The effect of lipid-lowering treatment target value on intracranial hemorrhage
Time of Update: 2022-01-08
hypertensionIt can be seen that, compared with the lipid-lowering treatment of 100±10mg/dL, controlling the LDL cholesterol of patients with atherosclerotic ischemic stroke to <70mg/dL does not significantly increase the risk of intracranial hemorrhage .
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Neurology: Cerebrospinal fluid Aβ38 levels are linked to Alzheimer's disease risk
Time of Update: 2022-01-08
studied whether Aβ38 levels in cerebrospinal fluid (CSF) are related to the risk of AD dementia and cognitive decline .
Study on the Correlation between Cerebrospinal Fluid Aβ38 and Clinical TransformationIn two independent clinical cohorts, higher CSF Aβ38 levels were associated with lower risk of AD-related changes .
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Neurology: The era of vascular therapy is coming, and patients with posterior circulation ischemia may usher in new opportunities!
Time of Update: 2022-01-08
Recently, experts from the Department of Radiology and Neurology at the University of Texas Southwestern Medical Center reviewed the clinical, imaging and anatomical features of posterior circulation ischemia (PCI), and dealt with basilar artery occlusion (BAO) Perform a systematic review of related results .
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"Ultrafine particles" may carry clues to cancer, Alzheimer's disease and COVID-19
Time of Update: 2022-01-08
Researchers at Vanderbilt University Medical Center (Vanderbilt University Medical Center) have discovered a kind of nanoparticles released from cells, called "supermere", which contains a variety of cancers, cardiovascular diseases, Alzheimer's Zheimer's disease and even COVID-19 related enzymes, proteins and RNA .
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JAMA Sub-Journal: Is your exercise in place?
Time of Update: 2022-01-08
references:Association of Physical Activity Level With Risk of Dementia in a Nationwide Cohort in Korea.
38526Association of Physical Activity Level With Risk of Dementia in a Nationwide Cohort in Korea.
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NEJM: Comparative analysis of CYP2C19 dysfunction carriers taking ticagrelor and clopidogrel on stroke or TIA
Time of Update: 2022-01-08
It can be seen that among Chinese patients with mild ischemic stroke or TIA with CYP2C19 loss-of-function alleles, the 90-day stroke risk after ticagrelor treatment is slightly lower than clopidogrel .
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Stroke: After a stroke, the function of the distal upper limbs and functional independence are closely related
Time of Update: 2022-01-08
The important significance of this study is that it found that despite some improvements, the less affected UE at 6 months after stroke was still below the standard, explaining the difficulties of ADL and instrumental ADL .
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Science Sub-Journal: The savior of "alcoholics"!
Time of Update: 2022-01-08
The relevant research results were recently published in the journal Science Advances, with the title of the paper "Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism" .
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Interesting science, snoring and insomnia, more likely to suffer from heart disease and higher risk of death
Time of Update: 2022-01-08
The study shows that people with both insomnia and obstructive sleep apnea are more likely to suffer from heart problems, and the likelihood of death is greater than The number of people without any disease is nearly 50% higher .
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Nature Sub-Journal: A new variant of AAV that breaks through the blood-brain barrier without being enriched in the liver
Time of Update: 2022-01-08
Recently, the California Institute of Technology Viviana Gradinaru team in Nature Neuroscience journal published a report entitled: AAV capsid variants with Transgene expression The Brain-Wide and Decreased liver Targeting the After intravenous Delivery in Mouse and marmoset research papers .
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Phytomedicine: Yiqi Fumai for injection (freeze-dried) reduces cerebral ischemic damage by inhibiting neuronal autophagy
Time of Update: 2022-01-08
Fluorescence colocalization results show that YQFM regulates the interaction of NMMHC IIA-F-actin-ATG9A, inhibits ATG9A translocation in MCAO/R mice, and reduces cerebral ischemia/reperfusion injury.
Conclusion: YQFM inhibits excessive autophagy and exerts neuroprotective effects by interfering with NMMHC IIA-actin-mediated ATG9A translocation .
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Alzheimers Dement: The implementation of memory care in nursing homes can reduce the risk of hospitalization for the elderly
Time of Update: 2022-01-08
Alzheimers Dement magazine published a research article comparing the admissions of patients with Alzheimer's disease and related dementia (ADRD) in nursing homes and hospitals with memory care assisted living and general assisted living .
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5 typical image signs, waiting for you to challenge?
Time of Update: 2022-01-08
Without relevant medical history, the results of a cranial MRI examination are as follows: Figure 2 Sagittal T1WI image shows that the cerebellar tonsils herniated down into the lower cervical spinal canal, the inferior hernia is greater than 6 mm, and there is no syringomyelia.
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NEJM: Liu Jianmin's team from Naval Military Medical University revealed that patients with acute anterior circulation large vessel occlusive ischemic stroke within 4.5 hours can be directly removed
Time of Update: 2022-01-08
A controlled study, covering 41 academic tertiary hospitals across the country, screened a total of 1586 patients with anterior circulation acute large vessel occlusive ischemic stroke with an onset of less than 4.
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Exposure to formaldehyde at work may cause cognitive problems
Time of Update: 2022-01-08
New research shows that long-term exposure to formaldehyde at work may be related to cognitive impairment in the future .
Compared with workers who have never been exposed to formaldehyde, workers who have been exposed to formaldehyde for 22 years or more have a 21% higher risk of cognitive impairment .
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Alzheimer & Dementia: The role of genetics in the pathogenesis of Alzheimer's——an analysis of the results of the LOAD family study
Time of Update: 2022-01-08
The National Institute on Aging Family Study of Late-Onset Alzheimer's Disease (NIA-LOAD FBS) is the largest collection of multiple AD families recruited and longitudinally evaluated globally .
12514The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery.
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Neuroradiology: Maybe we have overlooked the medulla oblongata watershed infarction
Time of Update: 2022-01-08
The characteristics of these patients are as follows:In November 2021, Andrea Zini from Italy and others reported in Neuroradiology 5 patients with bulbar watershed infarction.
In the schematic diagram of the upper medulla axial position, red represents the marginal zone area:The authors believe that atherosclerosis and arterial dissection rarely involve only the medulla oblongata.
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The main force in lowering uric acid can actually reduce the risk of myocardial infarction in patients with gout by as much as 50%!
Time of Update: 2022-01-08
Febuxostat is effective in cardiovascular mortality, myocardial infarction , stroke or comprehensive The outcome is not inferior to allopurinol, which is in sharp contrast with the results of the previously published CARES trial .
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Radiology: T1MRI hyperintensity in stable coronary artery disease is intraplaque hemorrhage rather than lipid components
Time of Update: 2022-01-08
compared CATCH MRI scans and near infrared spectroscopy (NIRS) intravascular ultrasound (IVUS) images to determine whether the main substrate of HIPs on T1-weighted images is intraplaque hemorrhage (IPH) or lipids .
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International Journal of Obesity: Get fat, get fat first
Time of Update: 2022-01-08
In addition, increased family obesity risk (eg, parental obesity and prevalence of T2D) is associated with decreased mu-opioid and CB1 receptor density and changes in brain glucose metabolism .
