Science Sub-Journal: The savior of "alcoholics"!

Alcohol dependence is one of the most common neuropsychiatric diseases
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In Germany, more than 5 million people are affected

Alcohol dependence is one of the most common neuropsychiatric diseases

In a new study, from the University of Heidelberg, Germany, France and Picardy Jules - Verne University researchers found that as to one kind of ecstasy from mushroom, psilocybin (psilocybin) has the potential to restore brain In the affected molecular circuits, thereby helping to reduce the recurrence of alcohol dependence

Cortical mGluR2 deletion is a pathological molecular mechanism of behavioral changes in addicts

The mental processes that control behavior, attention, and emotions are called executive functions
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In many mental illnesses and addictions such as attention deficit hyperactivity disorder (ADHD), autism, schizophrenia, and borderline syndrome, the ability to control one's thoughts and actions and regulate emotions is disturbed

The mental processes that control behavior, attention, and emotions are called executive functions

 

The lack of mGluR2 in the submarginal zone induced by alcohol can lead to impaired performance in the attention shift test
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Picture from Science Advances, 2021, doi:10.
1126/sciadv.

In this new study, the authors investigated the molecular mechanisms underlying changes in executive function and increased recurrence of alcohol dependence

Psilocybin restores the production of mGluR2 Psilocybin restores the production of mGluR2

Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) act on the serotonin 2A receptor (5-HT2AR) in the brain
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These receptors are abundant in the prefrontal cortex

Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) act on the serotonin 2A receptor (5-HT2AR) in the brain

The first author and co-corresponding author of the paper, Dr.

Reference materials:
Marcus W.
Meinhardt et al.
Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism.
Science Advances, 2021, doi:10.
1126/sciadv.
abh2399.
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