International Journal of Obesity: Get fat, get fat first

Obesity is a pressing global public health problem
.

There is an urgent need for new pharmacological methods to combat obesity and the accompanying increase in type 2 diabetes (T2D)

diabetes

Tatu Kantonen et al.
published a research article in the International Journal of Obesity.
They studied whether brain insulin signaling, μ-opioid receptor (MOR) and cannabinoid CB ₁ receptor (CB ₁ R) are related to obesity risk
.

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The subjects were 41 young non-obese men with variable obesity risk characteristics
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Obesity risk was assessed by subjects’ physical exercise habits, body mass index, and family risk factors, including parental obesity and T2D

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How to define the risk of familial obesity? The researchers assigned values ​​based on the subjects’ parents’ overweight/obese and type 2 diabetes (T2D) status, with an interval of 0-4
.

Many brain regions (frontotemporal lobe, cingulate cortex, hypothalamus, and bilateral insula and putamen) of people at high risk of obesity have significantly increased brain glucose uptake
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It can be seen that brain insulin resistance has occurred before obesity

The brain glucose uptake of multiple brain regions (frontotemporal lobe, cingulate cortex, hypothalamus, and bilateral insula and putamen) of people at high risk of obesity is significantly increased .

Bayesian stratification analysis showed that the risk of familial obesity was strongly correlated with brain glucose uptake in multiple brain regions
.

Changes in central insulin resistance and neuroreceptor signaling may lead to increased food intake and weight gain

Familial obesity risk is strongly correlated with brain glucose uptake in multiple brain areas.

The influence of familial obesity risk on central glucose uptake and μ-opioid receptor availability
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The influence of familial obesity risk on central glucose uptake and μ-opioid receptor availability
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The main finding of the study is that non-obese young men with a higher risk of obesity in the future have increased brain glucose uptake under insulin stimulation
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In addition, increased family obesity risk (eg, parental obesity and prevalence of T2D) is associated with decreased mu-opioid and CB1 receptor density and changes in brain glucose metabolism

Molecular and metabolic changes in the brain are also related to the risk of personal obesity
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The current findings complement the results previously reported in middle-aged obese subjects, suggesting that changes in brain insulin signaling and MOR and CB ₁ R neurotransmission may increase the risk of weight

Molecular and metabolic changes in the brain are also related to the risk of personal obesity

The genetic mechanism that promotes obesity may be partly mediated through the information system of insulin, opioids, and endocannabinoids in the brain
.
The genetic mechanism that promotes obesity may be partly mediated through the information system of insulin, opioids, and endocannabinoids in the brain
.

Original source

Kantonen, T.
, Pekkarinen, L.
, Karjalainen, T.
  et al.
 Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB ₁  receptor availability.
  Int J Obes  (2021).
https://doi.
org/10.
1038/s41366-021-00996-y

Kantonen, T.
, Pekkarinen, L.
, Karjalainen, T.
  et al.
₁ 1  receptor availability.
  Int J Obes  (2021).
https://doi.
org/10.
1038/s41366-021-00996-y Int J Obes https ://doi.
org/10.
1038/s41366-021-00996-y Leave a message here