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    Home > Active Ingredient News > Study of Nervous System > Stroke: The effect of lipid-lowering treatment target value on intracranial hemorrhage

    Stroke: The effect of lipid-lowering treatment target value on intracranial hemorrhage

    • Last Update: 2022-01-08
    • Source: Internet
    • Author: User
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    Although statin therapy has a secondary preventive effect on ischemic stroke , in some cases, statin therapy can increase the risk of intracranial hemorrhage .

    Stroke prevention

    Recently, the heart blood vessels published a research article on the disease areas prestigious journal Stroke, the objective of this lipid-lowering therapy in patients with stroke (TST) test, the researchers aimed for a pre-specified predictors of intracranial hemorrhage events were explored
    .

    Blood vessel

    Patients with ischemic stroke in the past 3 months or transient ischemic attack in the past 15 days and evidence of cerebrovascular or coronary atherosclerosis will be randomly assigned to the low lipid-lowering treatment target at a ratio of 1:1 Density lipoprotein (LDL) cholesterol is less than 70mg/dL or 100±10mg/dL, and the lipid-lowering drugs used by the subjects are statins or ezetimibe
    .

    cholesterol

    Among the 2860 patients included in the study, a total of 31 cases of intracranial hemorrhage occurred during a median follow-up of 3 years.
    Per 1000 patients per year [95%CI 2.


    38-4.


    hypertension

    It can be seen that, compared with the lipid-lowering treatment of 100±10mg/dL, controlling the LDL cholesterol of patients with atherosclerotic ischemic stroke to <70mg/dL does not significantly increase the risk of intracranial hemorrhage
    .
    Intracranial hemorrhage events are not related to lower LDL cholesterol levels


    .


    Compared with the lipid-lowering treatment of 100±10mg/dL, controlling the LDL cholesterol of patients with atherosclerotic ischemic stroke to <70mg/dL does not significantly increase the risk of intracranial hemorrhage


    Original source:

    Pierre Amarenco.


    et al.


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