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Although statin therapy has a secondary preventive effect on ischemic stroke , in some cases, statin therapy can increase the risk of intracranial hemorrhage .
Stroke preventionRecently, the heart blood vessels published a research article on the disease areas prestigious journal Stroke, the objective of this lipid-lowering therapy in patients with stroke (TST) test, the researchers aimed for a pre-specified predictors of intracranial hemorrhage events were explored
.
Patients with ischemic stroke in the past 3 months or transient ischemic attack in the past 15 days and evidence of cerebrovascular or coronary atherosclerosis will be randomly assigned to the low lipid-lowering treatment target at a ratio of 1:1 Density lipoprotein (LDL) cholesterol is less than 70mg/dL or 100±10mg/dL, and the lipid-lowering drugs used by the subjects are statins or ezetimibe
.
Among the 2860 patients included in the study, a total of 31 cases of intracranial hemorrhage occurred during a median follow-up of 3 years.
Per 1000 patients per year [95%CI 2.
38-4.
hypertension
It can be seen that, compared with the lipid-lowering treatment of 100±10mg/dL, controlling the LDL cholesterol of patients with atherosclerotic ischemic stroke to <70mg/dL does not significantly increase the risk of intracranial hemorrhage
.
Intracranial hemorrhage events are not related to lower LDL cholesterol levels
.
Compared with the lipid-lowering treatment of 100±10mg/dL, controlling the LDL cholesterol of patients with atherosclerotic ischemic stroke to <70mg/dL does not significantly increase the risk of intracranial hemorrhage
Original source:
Pierre Amarenco.
et al.