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Mol Psychiatry: The default network cortex is associated with creative thinking
Time of Update: 2022-01-23
Using a new experimental approach, the study demonstrated a causal relationship between the default network and creative fluency by directly stimulating the cerebral cortex to disrupt separately identified regions in the default network during a divergent thinking task in awake patients .
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Scientists identify gut-derived metabolite that plays a role in neurodegenerative disease
Time of Update: 2022-01-23
CUNY news on December 20 The important finding, published in the journal Brain , furthers scientists' understanding of how gut bacteria influence the course of neurological disease by producing compounds that are toxic to nerve cells .
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JAMA Sub-Journal of Migraine Patient Gospel-Evaluation of Safety and Efficacy of Irenatumab
Time of Update: 2022-01-23
In the double-blind treatment phase, overall, in patients with and without a history of aura, the erenazumab group had greater reductions in MMDs and AMSM days than the placebo group, and these reductions were seen throughout the expansion phase to keep .
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Acta Anaesthesiol Scand: Chronic Pain Following Unexpected Dural Incentives in Parturients: A Case-Control Prospective Observational Study
Time of Update: 2022-01-23
This study found no statistically significant difference in the development of chronic pain between conservatively treated and EBP-treated patients .
This study found no statistically significant difference in the development of chronic pain between conservatively and EBP-treated patients .
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Neurology: Outdoor exercise must be adapted to local conditions, and strenuous physical activity under air pollution may exacerbate brain health hazards!
Time of Update: 2022-01-23
Wrist accelerometers, multimodal MRI of T1 images and T2 FLAIR data, and land use regression were used to assess vigorous physical activity (VigPA) , structural brain volume, and air pollution (AP) in subgroups of the full sample, respectively .
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CEREBRAL CORTEX: Does music and foreign language training make a difference in improving auditory function at school age?
Time of Update: 2022-01-23
MMN amplitude (μV) (mean (SD)) of Fz and latency (ms) before and after training in the control, English, and music groups in the melodic paradigmThey found that language promotes auditory-predictive brain processes in early childhood more than music .
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Frontiers: Associations between dementia-related markers and physical activity in cognitively normal older adults
Time of Update: 2022-01-23
Further analysis revealed that the ratios of Aβ1-40/Aβ1-42 and APP669-711/Aβ1-42, which were associated with higher brain amyloidosis in previous studies, differed between APOE ε4 carriers and non-carriers .
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Neurology: The global burden of ischemic stroke from 1990 to 2019: The age-standardized incidence rate (ASIR) increased most significantly in China, and the burden of ischemic stroke in women worldwide is larger, especially in the elderly
Time of Update: 2022-01-23
Annual Estimated Percentage Change (EAPC) Social Development Index (SDI) No comprehensive update on the descriptive epidemiology and trends of ischemic stroke has been published since the 2017 GBD, examining ischemic stroke at global, regional and national levels from a gender, age and social development index (SDI) perspective burden .
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European Radiology: How to achieve undifferentiated MTA assessment among radiologists with different clinical experience?
Time of Update: 2022-01-23
The present study shows that when the Scheltens MTA scale was used to score MTA in non-demented populations, radiologists with different clinical experience reached sufficient agreement across different modalities with similar accuracy .
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Neurology: Independent of traditional vascular risk factors, circulating interleukin-6 (IL-6) levels are positively and linearly associated with long-term risk of developing ischemic stroke!
Time of Update: 2022-01-23
We conducted a systematic review and meta-analysis using pooled data from the published literature and unpublished cohort studies to explore the association of circulating IL-6 levels with the risk of ischemic stroke in a population-based prospective cohort study .
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Stroke: Hypertensive disorders of pregnancy, how does it affect stroke risk?
Time of Update: 2022-01-23
In this 17-year nationwide cohort study, Shih-Kai Hung et al, Dalin Tzu Chi Hospital, Taiwan, China, assessed bleeding and ischemic stroke risk in women with HDP stratified by duration of follow-up .
Among the 4 HDP subtypes, chronic hypertension plus preeclampsia had the highest risk of stroke (aHR=3.
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Neurology: Memory declines sharply after first stroke and recurrent stroke, endovascular treatment may prevent more memory loss after stroke
Time of Update: 2022-01-23
48), respectively, independent of a range of confounders ;In the case group, the mean acute decline in memory scores after first stroke and recurrent stroke was 0.
05] words/year);Mean acute declines in memory scores after first stroke and recurrent stroke were smaller in countries with better access to endovascular treatment .
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JNNP: Possible predictors of phenotypic switch in isolated REM sleep behavior disorder: a systematic review and meta-analysis
Time of Update: 2022-01-22
Growing evidence suggests that iRBD patients who exhibit specific clinical symptoms (eg, motor dysfunction, autonomic dysfunction, anosmia, color vision abnormalities, cognitive impairment, and depression) are at higher risk for phenotypic switching .
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Sci Adv: Monosynaptic Analysis in Alzheimer's Disease
Time of Update: 2022-01-22
When ADNC was compared to the control group, the mean percentage of presynaptic positive events was significantly different for the two antibody probes, with more PHF-tau in the hippocampus and less DJ1 in BA9 (Fig.
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Stroke: Cardiogenic risk factors for ischemic stroke
Time of Update: 2022-01-22
The significance of this study is its finding that existing genetic data do not support a substantial impact of cardiac characteristics on stroke risk beyond known clinical risk factors .
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Is energy the key to Alzheimer's disease?
Time of Update: 2022-01-22
Use of oxygen in cells to produce energy Zebrafish Lead researcher Dr Karissa Barthelson, from the Alzheimer's Disease Genetics Laboratory at the University of Adelaide, said: "This is very interesting because we know that when Alzheimer's disease eventually develops, people's brains become severely deprived of energy .
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Double the risk of female infertility, and the culprit is... snoring?
Time of Update: 2022-01-22
Obstructive sleep apnea increases risk of female infertility: A 14-year nationwide population-based study.
Obstructive sleep apnea increases risk of female infertility: A 14-year nationwide population-based study.
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Nature Biomedical Engineering: Targeting mitophagy to clear brain "garbage" to treat Alzheimer's disease
Time of Update: 2022-01-22
This study screened a large number of small molecules based on machine learning and found two lead compounds with the potential to treat Alzheimer's disease .
Interestingly, these mitophagy-inducing agents can effectively improve neuronal function, reduce Alzheimer's disease-related pathological changes, and enhance learning and memory in animal models .
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JNNP: Characterization of TRIM46 Autoantibody-Associated Nervous System Paraneoplastic Syndromes
Time of Update: 2022-01-22
The study initially described a triple motif-containing protein 46 (TRIM46) IgG staining pattern in a patient with paraneoplastic encephalomyelitis and small cell lung cancer (SCLC) .
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Neurology: Traumatic brain injury increases the risk of late-onset epilepsy, especially repeated blows, severe injuries, and advanced age
Time of Update: 2022-01-22
The primary objective of this study was to determine the link between head injury and the development of epilepsy at age 67 or older (a two-year epilepsy-free period was allowed after Medicare eligibility to determine epilepsy events), adjusting for LOE Demographics and other risk factors .
