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Rapid eye movement (REM) sleep behavior disorder (RBD), a parasomnia characterized by dreaming behavior and loss of normal muscle tone during REM sleep , is divided into isolated RBD (iRBD) and symptomatic RBD
.
iRBD is actually a distinct preclinical sign of α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)
The tonic prodromal interval is markedly long and varies among individuals, providing an opportunity for possible disease-modifying therapy
Prevention This article was published in the Journal of Neurology, Neurosurgery & Psychiatry .
PubMed, Web of Science, and ClinicalTrials.
gov were searched through June 2021 to identify possible predictors of phenotypic transition from iRBD to Parkinson's disease (PD)
.
Pooled HRs and standardized mean differences (SMDs) with 95% CIs were calculated using fixed-effects or random-effects models
flow chart
A total of 123 studies were included in the meta-analysis
.
Significant motor dysfunction (HR 1.
The process was also imaged by shell dopamine transporter (HR 2.
Possible predictors of phenotypic switch based on iRBD versus PD patients in studies estimating SMD
This is the first comprehensive systematic review and meta-analysis to identify potential predictors of phenotypic transformation in iRBD patients
.
To maximize generality and eventual scalability, focus on markers available in all relevant studies to date
When patients have a UPDRS III score >3.
WangC ,ChenF ,LiY WangCWang ChenFChen LiYLi, et alPossible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and meta-analysisJournal of Neurology, Neurosurgery & PsychiatryPublished Online First:22 December 2021.
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