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Sci Adv: Monosynaptic Analysis in Alzheimer's Disease
Time of Update: 2022-01-22
When ADNC was compared to the control group, the mean percentage of presynaptic positive events was significantly different for the two antibody probes, with more PHF-tau in the hippocampus and less DJ1 in BA9 (Fig.
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JNNP: Possible predictors of phenotypic switch in isolated REM sleep behavior disorder: a systematic review and meta-analysis
Time of Update: 2022-01-22
Growing evidence suggests that iRBD patients who exhibit specific clinical symptoms (eg, motor dysfunction, autonomic dysfunction, anosmia, color vision abnormalities, cognitive impairment, and depression) are at higher risk for phenotypic switching .
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Neurology: Traumatic brain injury increases the risk of late-onset epilepsy, especially repeated blows, severe injuries, and advanced age
Time of Update: 2022-01-22
The primary objective of this study was to determine the link between head injury and the development of epilepsy at age 67 or older (a two-year epilepsy-free period was allowed after Medicare eligibility to determine epilepsy events), adjusting for LOE Demographics and other risk factors .
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Stroke: Cardiogenic risk factors for ischemic stroke
Time of Update: 2022-01-22
The significance of this study is its finding that existing genetic data do not support a substantial impact of cardiac characteristics on stroke risk beyond known clinical risk factors .
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How to identify 2 different types of positional vertigo?
Time of Update: 2022-01-22
But in fact, some of the clinically diagnosed cases of BPPV are actually misdiagnosed by other diseases, such as central positional vertigo (CPPV) .
But in fact, in cases of clinical diagnosis of BPPV, the diagnosis is actually a misdiagnosis of other diseases, such as central positional vertigo (CPPV) .
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Neurology: A multicenter combined cohort confirms that plasma amyloid Aβ 42/40 reliably detects amyloid plaques in Alzheimer's disease
Time of Update: 2022-01-22
We used samples collected at multiple centers using different blood collection and processing protocols to determine the accuracy of plasma Aβ42/Aβ40 assays in classifying amyloid PET status in a global study .
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JAMA Netw Open: Stop-and-go elderly with slow gait reduces risk of cognitive impairment
Time of Update: 2022-01-22
recently published research in the journal JAMA Netw Open evaluating whether low activity fragmentation in older adults with slow gait is a neural cause of slow walking, putting these individuals at higher risk for AD .
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Lancet Psychiatry: Drug addiction changes?
Time of Update: 2022-01-22
To investigate whether the rates of self-harm and suicide differ between people receiving opioid agonist therapy during initiation, cessation, and the remainder of time with and without treatment, experts from Population Health Sciences, University of Bristol School of Medicine, UK, conducted a correlation The study, the results were published in the journal Lancet Psychiatry.
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JNNP: frailty, lifestyle, genetics and dementia risk
Time of Update: 2022-01-22
Another possibility is that a healthy life> dementia by slowing the rate of ageing -- the associated accumulation of health deficits, also known as frailty .
High frailty was associated with an increased risk of dementia, independent of genetic risk (HR 3.
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Neurology: Overview of the risk of cerebral venous sinus thrombosis after 4 SARS-CoV-2 vaccinations, young people bear the brunt
Time of Update: 2022-01-22
Age < 60 years old The risk of developing CVST with thrombocytopenia within 28 days of the first ChAdOx1 NCoV-19 vaccine was higher in younger populations .
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Stroke: 20 years of follow-up, what about long-term mortality after childhood stroke
Time of Update: 2022-01-22
Using Cox proportional hazards regression models, overall and cause-specific mortality risks were calculated for pediatric ischemic stroke patients and their first-degree relatives .
The significance of the study lies in its findings: Long-term mortality increases after pediatric ischemic stroke , and even after 20 years, neurological disorders are the most common cause of death .
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Guidelines & Consensus 14 Recommendations for Discontinuation of Antiepileptic Drugs in Seizure-Free Epilepsy Patients (AAN Guideline Recommendations)
Time of Update: 2022-01-22
Proposed Statement 3cProposed Statement 3cAlthough available data do not suggest an increased risk of status epilepticus or death after ASM discontinuation, clinicians should inform families that recurrent seizures put children at risk for status epilepticus and death (Grade B) .
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Stroke: Gender differences in intracranial aneurysm rupture rates
Time of Update: 2022-01-22
This may be due to a higher prevalence of female patients or aneurysm-related rupture risk factors compared with males, or the underpowered previous studies .
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JAMA Network Open: Controlling uric acid and avoiding gout may reduce the risk of lower extremity amputation
Time of Update: 2022-01-22
In gout patients, poor control of serum uric acid (mean 7 mg/dL in the previous year) was associated with a 25% to 37% increase in amputation rates .
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Stroke: a new quantitative score that can more effectively predict posterior circulation ischemia
Time of Update: 2022-01-22
, University of Melbourne, assessed the prognostic value of additional clinical features in conservatively treated patients with posterior circulation stroke and mild-to-moderate symptoms (NIHSS score <10), and used this information to derive and validate NIHSS A modified version, ie Post-NIHSS (POST-NIHSS) .
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Dr. Xu Guixing｜Cranial MR Image Reading Hand-painted (New)
Time of Update: 2022-01-22
First Release: Neural Time Author: Dr.
Xu GuixingFirst Release: Neural Time Author: Dr.
Participated in compiling 3 books, of which 1 was the second chief editor .
Participated in compiling 3 books, of which 1 was the second chief editor .
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Mov Disord.: 7T MRI found impaired structural connectivity between brainstem nuclei in patients with REM sleep behavior disorder
Time of Update: 2022-01-22
The brainstem pathophysiological basis of REM sleep behavior disorder has been described in animal models, but has not been adequately studied in humans due to the lack of in vivo brainstem nuclear atlas and limited magnetic resonance imaging (MRI) sensitivity .
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JNNP: Model Design for Predicting Recovery Outcomes After Stroke
Time of Update: 2022-01-22
e. , to what extent can an individual patient's motor recovery be predicted?The prevailing view in the field of upper extremity motor recovery is that patients should be divided into severely and non-severely affected groups when modeling motor recovery from stroke in general and when studying biomarkers and rehabilitation development in particular .
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Alternative strategies to delay neurodegeneration in Alzheimer's disease
Time of Update: 2022-01-22
In 39 patients with mild cognitive impairment (MCI), 6 months of atomoxetine treatment reduced Tau levels in study participants' cerebrospinal fluid (CSF) and normalized other neuroinflammatory markers The study points to an alternative drug strategy for Alzheimer's disease that does not rely on antibodies against Tau or another Alzheimer's-related protein, beta-amyloid .
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Stroke: Blood-brain barrier disruption and hypoperfusion associated with cerebral edema after ischemic stroke
Time of Update: 2022-01-22
We then explored the relationship between BBB disruption and intra-infarct cerebral blood flow and assessed cerebral edema using 2 metrics: first, midline shift (MLS), which was classified as negligible (<1 mm), mild (≥1 to <5 mm) or severe (≥5 mm), followed by relative hemisphere volume (rHV), defined as the ratio of the 3-dimensional volume of the ischemic hemisphere relative to the contralateral hemisphere .
