JNNP: frailty, lifestyle, genetics and dementia risk

As the population ages, the number of people with dementia is increasing, resulting in an increased personal and socioeconomic burden
.

Even so, some high-income countries have seen significant declines in Alzheimer's rates, and it is unclear from the observational data whether adhering to a healthy life>

Adherence to a healthy life>
.

Cardiovascular risk factors are strongly associated with increased incidence of dementia, but limited evidence suggests that a healthy life>

Vascular prevention frailty is a detrimental health condition that broadly increases the risk of adverse health outcomes, including mortality

This article was published in the Journal of Neurology, Neurosurgery & Psychiatry .

502 493 individuals were recruited and a comprehensive baseline assessment of health and function was performed
.

This includes self-reported data on life>

Existing, validated polygenic risk scores for dementia were used

Data analysis flow chart

The mean age of the analyzed sample at baseline was 64.
1 years (SD=2.
9), and 53% were female
.

Dementia events were detected in 1762 participants (median follow-up = 8.

Higher genetic risk had the greatest effect on those with low frailty (HR 1.

Frailty and occasional dementia

Frailty and occasional dementia

This article investigates how overall health, as expressed by frailty index scores, combines with healthy life>
.

We report four key findings: (1) frailty is associated with a significantly increased risk of dementia independent of genetic risk; (2) almost half of the association between healthy life>

These results support the idea that dementia is a multiple-determined disease, shed light on how frailty and genetic predisposition interact, and identify frailty as a key modifiable risk factor for dementia that can be achieved through healthy living Manner behavior as target These results support the notion that dementia is a multiple-determined disease, shed light on how frailty and genetic predisposition interact, and identify frailty as a key modifiable risk factor for dementia that can Target through healthy life>

Frailty is strongly associated with dementia risk and affects risk attributable to genetic factors
.

Frailty should be considered an important modifiable risk factor for dementia and a target for dementia prevention strategies, even in populations with high genetic risk

WardDD ,RansonJM ,WallaceLMK Ward  DDWard Ranson  JMRanson Wallace  LMKWallace, et alFrailty, life>Journal of Neurology, Neurosurgery & Psychiatry  Published Online First:  21 December 2021.
 Published Online First: doi:  10.
1136 /jnnp-2021-327396doi:

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