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JAMA Sub-issue: Outpatient or inpatient?
Time of Update: 2022-01-22
consensusTo estimate and compare the risk of subsequent ischemic stroke in patients with TIA or minor ischemic stroke (mIS) in different care settings, experts from the University of Pennsylvania Neuroscience Institute conducted a meta-study published in JAMA in Network Open magazine .
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JAMA Neurology: COMT inhibitors are ineffective in adjunctive levodopa therapy for Parkinson's
Time of Update: 2022-01-22
Long-term Effectiveness of Adjuvant Treatment With Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared With Dopamine Agonists Among Patients With Parkinson Disease Uncontrolled by Levodopa Therapy JAMA Neurol.
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JNNP: A clinical trial endpoint study of amyotrophic lateral sclerosis based on patient preference
Time of Update: 2022-01-22
Therefore, in the present study, a new composite endpoint was proposed for randomized controlled clinical trials of ALS based on patient preferences for functional domains, thus weighing treatment effects against the actual needs of the patient population .
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Lancet Neurol: Blood Biomarkers for Alzheimer's Disease: Towards Clinical Application
Time of Update: 2022-01-22
Recently, "Lancet Neurol" published an article titled "Blood-based biomarkers for Alzheimer's disease: towards clinical implementation", the author gave a comprehensive overview of recent progress, focusing on the three biomarkers closest to the clinic: Aβ, pTau and NfL .
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JAMA Network Open: AI AI accurately predicts who will develop dementia within two years
Time of Update: 2022-01-22
Recently, researchers from the University of Exeter Medical School in the United Kingdom published a research paper titled: Performance of Machine Learning Algorithms for Predicting Progression to Dementia in Memory Clinic Patients in JAMA Network Open, a sub-journal of JAMA .
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Stroke: Blood pressure goals in the first 6 hours after endovascular therapy for stroke
Time of Update: 2022-01-22
Two observational studies found that peak systolic blood pressure (SBP) 24 hours after stroke was associated with an increased risk of symptomatic intracranial hemorrhage (sICH) and functional dependence .
Higher maximal SBP (per 10 mmHg increase) was associated with worse functional outcomes [(adjusted OR, 0.
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Age&Ageing: Functional task exercise significantly improves the daily problem-solving ability and functional status of the elderly with mild cognitive impairment
Time of Update: 2022-01-22
To investigate the effect of functional task exercise on the daily problem-solving ability and functional status of older adults with MCI compared with single exercise or cognitive training and no treatment control group, experts from the School of Medicine and Hygiene, Tung Wah University, Hong Kong conducted a A single-blind, four-arm randomized controlled trial .
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JAMA Psychiatry: Cognitive behavioral therapy significantly improves the risk of depression and depression relapse in patients with insomnia!
Time of Update: 2022-01-22
The results of this randomized clinical trial suggest that treating insomnia with CBT-I has an overall benefit in preventing the occurrence and recurrence of major depressive disorder in older adults with insomnia .
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Stroke: Cerebral small vessel disease, oxygen metabolic stress and white matter damage are closely related
Time of Update: 2022-01-22
Neuroimaging endpoints have been used to measure damage from cerebral small vessel disease (CSVD), including white matter hyperdensity (WMH), lacunar stroke, cerebral microbleeds, atrophy, enlargement of the perivascular space, and impaired microstructural integrity.
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Neurology: Comprehensive multi-study, MRI diagnosis of focal cortical dysplasia refractory epilepsy postoperative excellent prognosis rate of 70%
Time of Update: 2022-01-21
The problems to be solved include the following:To address this gap in understanding, we conducted a systematic review and meta-analysis of the existing literature to identify rates and predictors of favorable outcomes for seizures detected by MRI after FCD surgery .
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Neurology: CT/MRI perfusion imaging identifies post-thrombectomy cerebral no-reflow and is associated with treatment complications and poor 3-month prognosis
Time of Update: 2022-01-21
To address the uncertainty of stroke no-reflow in humans, we performed a pooled analysis of 3 prospective international multicenter thrombectomy randomized controlled trials using prespecified follow-up perfusion imaging and core laboratory Adjudicated angiographic assessment to investigate the prevalence of cerebral no-reflow in humans and whether it is associated with adverse radiological and clinical outcomes .
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Neurology: A pooled analysis of ATACH-2 and MISTIE III clinical trials—patients with primary intracerebral hemorrhage with underlying small vessel disease have less blood loss, a lower chance of hematoma expansion, or a better prognosis
Time of Update: 2022-01-21
To investigate the relationship between cerebral microbleeds (CMBS) and acute hematoma characteristics in patients with primary intracerebral hemorrhage (ICH) by collecting complete data from two large international clinical trials .
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Neurosci Bull︱ Li Yunqing’s research team reveals that changes in nerve plasticity in the anterior cingulate gyrus are related to hyperalgesia and anxiety in chronic pancreatitis
Time of Update: 2022-01-10
On December 15, 2021, the team of Professor Yunqing Li from the Air Force Military Medical University of the People’s Liberation Army and the Department of Human Anatomy of Guangxi Medical University published a study titled "Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats" on Neuroscience Bulletin.
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"Nature" Sub-Journal: There is no end to doing bad things!
Time of Update: 2022-01-10
Thomas Blank from the University of Freiburg, Germany, and his colleagues found that as we age, the more delta-VB produced by the metabolism of the intestinal flora, which causes the delta-VB levels in serum and brain to rise .
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Cereb Cortex Peng Ziwen/Chen Qi's group reveals the multimodal neuroimaging features of compulsive behavior acquisition
Time of Update: 2022-01-10
In response to these problems, Peng Ziwen’s research group from the School of Psychology, South China Normal University recently published an article titled "Imbalance in Functional and Structural Connectivity Underlying Goal-directed and Habitual Learning Systems in Obsessive Compulsive Disorder" in Cerebral Cortex, explaining Abnormal characteristics of the goal-oriented-habitual behavior learning system related to obsessive-compulsive behavior acquisition in patients with obsessive-compulsive disorder.
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Orbital pain, vision loss and orbital murmur, don’t miss the cause
Time of Update: 2022-01-10
① Direct CCF causes high-flow arteriovenous shunt between the internal carotid artery and cavernous sinus with relatively acute onset symptoms, including pulsatile exophthalmos, orbital murmur, bulbar conjunctival edema, and occasional intracranial hemorrhage .
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The prion disease that must die after the onset of disease ushered in a turnaround, and its lethal mechanism was cracked
Time of Update: 2022-01-10
Nine years later, she died of Creutzfeldt-Jakob disease caused by prion infection .
Gedusek also won the 1976 Nobel Prize in Physiology or Medicine for discovering Kuru's disease, a new type of pathogenicity and transmission mechanism, and eliminating this deadly disease .
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Exercise for nothing?
Time of Update: 2022-01-10
The results of an epidemiological cohort study showed that compared with participants who exercised vigorously for 30 minutes or more per week, nitrogen dioxide (NO2) and white matter hyperintensity volume ( The correlation between WMHV) is stronger .
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Develop a new staging system for brain tumors where the TNM staging system is not applicable
Time of Update: 2022-01-10
This article is from NEJM Journal Watch Developing an Imaging-Based Staging System for Brain Tumors.
The new imaging-based staging system is predictable The survival rate of glioma patients can guide the future brain tumor classification system .
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Progress in research on the pathogenic mechanism of hereditary spastic paraplegia
Time of Update: 2022-01-10
The study carried out linkage analysis and Sanger sequencing of genetic disease families, combined with cell line model analysis, and found that the truncated protein spastin encoded by the pathogenic gene SPAST of hereditary spastic paraplegia (HSP) can interfere with microbes in an isoform-specific manner.
