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How to recognize and manage acute migraine, one article
Time of Update: 2022-01-10
For clinicians, to better understand how potential triggers cause migraine, the most important thing is to understand: (1) the heterogeneity of triggers; (2) perceptual triggers The frequency and intensity of the factors; (3) the patient’s effort to control the triggers, and (4) the subtle difference between the true triggers of migraine and the aura symptoms .
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Nature Sub-Journal: Clinical Trial of Antisense Oligonucleotide Drugs for Treatment of Frostbite
Time of Update: 2022-01-10
Next, the research team conducted a human clinical trial of the ASO drug on a patient with gradual freezing disease with abnormal amplification of the C9orf72 gene GGGGCC .
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Neuro-Oncology Shanghai Jiaotong University Professor Wu Hao's team discovered a new mechanism for the development and development of auditory nerve tumors in NF2 patients
Time of Update: 2022-01-10
Evidence from molecular genetic studies shows that biallelic inactivation of NF2 based on the "second hit" theory is the main cause of acoustic neuroma tumor formation in NF2 patients .
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Neuron: It hurts to breathe!
Time of Update: 2022-01-10
Figure 1: Changes in respiratory behavior after activating or inhibiting PBL-Oprm1 neurons Increase, while other types of neurons in the lateral PB brain area do not encode behavioral information related to breathing .
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Nature Sub-Journal: Fighting with Poison!
Time of Update: 2022-01-10
After specifically knocking out Scn10a-positive DRG or ANTXR2 on peripheral somatosensory neurons, intrathecal injection of edema toxin did not cause analgesic effects .
In summary, this article reveals that the receptor ANTXR2, which is enriched in DRG expression, mediates the analgesic effect of anthrax toxin .
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To prevent Alzheimer's disease, environment and lifestyle are more important than genetics! Professor Ji Sihan of Tsinghua University interprets 3 important research results
Time of Update: 2022-01-10
▎Alzheimer's disease (AD), edited by WuXi AppTec's content team, is the most common type of dementia. As a degenerative disease of the nervous system, its pathogenesis is complex and currently canno
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MNFR: Afraid of dementia when you grow old?
Time of Update: 2022-01-10
Scientists from the University of Barcelona and other institutions approved Studies have found that a diet rich in plant-based products may reduce the risk of cognitive impairment and dementia in the elderly .
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All cases of cerebral infarction and paralysis above, the diagnosis is quite different...
Time of Update: 2022-01-10
This disease often manifests as numbness and weakness of the contralateral limb, central facial and tongue paralysis, and slurred speech .
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What are the reasons for frequent chest tightness and shortness of breath in patients with cerebral infarction?
Time of Update: 2022-01-10
Figure 1 Head MRI performance 03 case analysis and treatment process The patient was diagnosed with acute cerebral infarction (the cause is considered to be aortic atherosclerosis), multiple myeloma, diabetes, but frequent shortness of breath and blood oxygen saturation 99% .
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Sudden headache, fever, unconsciousness, this lesion is very hidden
Time of Update: 2022-01-10
▌ Clinical image analysis T2WI and FLAIR (figure AD) showed that the basal ganglia (obvious on the right) were piled or scattered in small dots (about 1mm) with high signal intensity, and the other side of the left lateral ventricle, left occipital lobe and right cerebellum A small circular high-intensity shadow with a size of about 3 mm can be seen, and the surrounding area of the lesion is clear .
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Sci Adv Cang Chunlei team identified a new lysosomal chloride channel CLN7
Time of Update: 2022-01-10
On December 15, 2021, Cang Chunlei's research group from the Department of Life Sciences and Medicine of the University of Science and Technology of China published a research paper titled CLN7 is an organellar chloride channel regulating lysosomal function on Science Advances .
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JAMA Sub-Journal: Carbamazepine vs. Lamotrigine, who is "better" in treating epilepsy?
Time of Update: 2022-01-10
Recently, Larsson D and others published a paper on JAMA Neurol in the Journal of the American Medical Association-Neurology.
1. Click on the business card below to follow the official account of "Clinical Assistant in the Medical Field" 2.
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Herpes simplex viral encephalitis, SUSAC syndrome, hypertrophic lower olive nucleus degeneration, 3 minutes reading, 38 period
Time of Update: 2022-01-10
Case analysis: Herpes simplex virus encephalitis type 1 causes brain parenchymal infection, the clinical manifestations are infectious disease course, limbic system involvement manifestations, cognitive changes, disturbance of consciousness, epilepsy, etc.
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Neuron︱ Cao Peng laboratory discovers the closed-loop neural mechanism of repetitive stereotyped behaviors
Time of Update: 2022-01-10
These data indicate that the Cbln2+ Sp5C neurons projecting to the spinal cord may play a key role in the repetitive stereotyped behaviors of facial self-grooming in mice (Figure 6) .
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Fampridine Sustained-Release Tablets: High-quality real-world evidence helps patients to "win" step by step-Interviews with Professor Dong Qiang and Professor Feng Huiyu
Time of Update: 2022-01-10
As the world’s first and only drug approved for improving the walking ability of adult patients with multiple sclerosis (MS) combined with walking dysfunction (EDSS score 4-7) [1-4], Fampridine Sustained-Release Tablets (Compobi Neng™) was approved in China on May 11, 2021, and was included in the 2021 edition of the National Medical Insurance Drug List on December 3 of the same year, bringing good news to MS patients with combined walking dysfunction in China .
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The new phenotype of MOG antibody disease defined for the first time in 2017, doctors in Shennai must be aware of!
Time of Update: 2022-01-10
One side of CCE with seizures is considered to be a specific clinical phenotype of MOG antibody disease .
[2]Tao R,Qin C,Chen M,Yu HH,Wu LJ,Bu BT,Tian DS (2020) Unilateral cerebral cortical encephalitis with epilepsy: a possible special phenotype of MOG antibody -associated disorders.
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my country's neuroimmune disease laboratory diagnosis industry standards are about to be promulgated
Time of Update: 2022-01-10
Neuroimmune diseases include multiple sclerosis, neuromyelitis optica spectrum diseases, myelin oligodendrocyte glycoprotein (MOG) antibody-related diseases, autoimmune encephalitis, myasthenia gravi
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How to realize the early diagnosis and treatment of Alzheimer's disease
Time of Update: 2022-01-10
” The greatest hope for achieving better early diagnosis and treatment, and truly changing the course of AD disease, is new drugs targeting pathological proteins such as Aβ or tau, said Professor Xiaochun Chen "The lack of effective treatment is the biggest shortcoming that has restricted the treatment of AD in the past.
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Cell sensory neuron response is achieved through transcriptome changes
Time of Update: 2022-01-10
To this end, the authors hope to use single-cell RNA-seq to detect large-scale transcriptional changes in different known olfactory neurons, thereby It responds to how olfactory neurons adapt to environmental cues when the environment changes (Figure 1) .
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One picture takes you to comprehensively optimize the treatment of elderly patients with preoperative cerebrovascular diseases and old strokes (collection is recommended)
Time of Update: 2022-01-10
a. Patients with stable coronary heart disease who have previously placed bare metal stents are recommended to postpone elective surgery to at least 4 weeks, preferably 3 months, and continue to use as much as possible in the perioperative period on the basis of weighing the risk of surgical bleeding and stent thrombosis.
