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Headache, malignancy, vomiting... pay attention to the differential diagnosis
Time of Update: 2022-01-10
C. In the MRI T2/FLAIR sequence, ventriculitis is manifested as a significant thin layer of ependymal enhancement, running along the edge of the ventricle .
Layered debris deposits are more common in the ventricle, which manifests as limited diffusion in the case of purulent infection .
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[Guideline Consensus] Elderly Perioperative Guidelines (2020 Edition)·Management of Myocardial Ischemia Injury and Stroke
Time of Update: 2022-01-10
However, patients who have not used β-blockers for a long time before surgery are not recommended to use large doses during the perioperative period, otherwise it may increase the incidence of stroke and mortality .
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Treatment of Alzheimer's disease, RNAi therapy advances to the clinic
Time of Update: 2022-01-10
December 26, 2021/eMedClub News/--On December 22, 2021, RNAi therapy company Alnylam announced that it has submitted a clinical trial application (CTA) to the British Medicines and Healthcare Products Regulatory Agency (MHRA) ) To start the phase 1 study of ALN-APP .
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The brain-protecting artifact "Coffee + Tea" reduces the risk of stroke/dementia by about 30%
Time of Update: 2022-01-09
are all influencing factors of vascular dementia after ischemic stroke, and mastering the related factors can provide reliable theoretical basis for guiding prevention and clinical treatment [2 ] .
1. Click on the business card below to follow the official account of "Clinical Assistant in the Medical Field" 2.
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Early adolescent girls, development and movement delay, do you know this rare genetic disease?
Time of Update: 2022-01-09
C. Imaging shows a giant skull and an enlarged VR gap, which is caused by abnormal accumulation of mucopolysaccharides .
C. MPS can cause mental retardation and motor retardation, and the enlarged PV gap is adjacent to the abnormal signal fusion zone .
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Headache, dizziness and weak left limbs for 1 week, you need to be alert when encountering cystic lesions
Time of Update: 2022-01-09
T1WI (Figure C) showed enhancement of the cyst wall with enhancement of mural nodules, excluding the diagnosis of cysticercosis as a brain metastasis .
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Stroke prevention in high-risk patients with atrial fibrillation, left atrial appendage occlusion or NOAC? PRAGUE-17 study 4-year follow-up results announced
Time of Update: 2022-01-09
Conclusion The long-term follow-up results of the PRAGUE-17 study showed that for patients with nonvalvular atrial fibrillation at high risk of stroke and bleeding, cardiogenic thromboembolic events, cardiovascular deaths, clinically related bleeding, and surgical/device-related complications in the LAAC treatment group The composite endpoint is not inferior to the NOAC treatment group .
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12-year follow-up study: Chronic disease has an extraordinary impact on the brain!
Time of Update: 2022-01-09
" "Our research shows that under general anesthesia more than Patients undergoing one operation have almost no effect on long-term cognitive decline, but there are subtle impairments in information processing ability, selective attention, execution, and mental speed .
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Nat Aging︱Alzheimer’s disease new discovery: a regulatory mechanism of bone marrow-derived macrophages that do not rely on the TREM2 pathway
Time of Update: 2022-01-09
, Nat Aging, 2021) In order to explore the role of MDM in AD models, researchers used anti-PD- Trem2-/-5xFAD mice (without DAM) aged 6-9 months were treated with L1 or IgG2b antibody, and behavioral observations were performed on the mice 27-30 days after the antibody injection (Figure 2a) .
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Important experts gathered, what are the highlights of this Guangdong-Hong Kong-Macao Greater Bay Area Neuroimmune Basic and Clinical Translation Symposium?
Time of Update: 2022-01-09
Figure 2: Application of stem cell therapy in spinal cord injury Professor Guan Yangtai, Renji Hospital, Shanghai Jiaotong University School of Medicine, also shared the progress of human umbilical cord mesenchymal stem cells (hUC-MSC) in the treatment of neuromyelitis optica spectrum disease (NMOSD) .
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AADC gene therapy brings hope to Parkinson's disease patients
Time of Update: 2022-01-09
The researchers published the 36-month safety and clinical outcome of NBIb-1817 (VY-AADC01, an investigational gene therapy for the treatment of Parkinson's disease [not yet FDA approved]) Phase 1b, an open-label, dose-escalation trial .
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How to diagnose epileptic seizures in a 21-year-old man through imaging?
Time of Update: 2022-01-09
3. 0T MR coronal FLAIR image shows that the right hippocampus is smaller than the left, and the normal internal gray matter is unclear .
▌ The main features of the image: abnormally high signal on T2, the hippocampus becomes smaller/shrinked, and the internal structure is unclear .
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Microbiome doesn't eat fruits and vegetables, it hurts my brain!
Time of Update: 2022-01-09
In conclusion, this study reports for the first time that a diet lacking fiber leads to cognitive impairment by altering the gut microbiota-hippocampal axis, which is pathologically different from normal brain aging .
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Multiple sclerosis treatment only focuses on recurrence and disability progression?
Time of Update: 2022-01-09
Studies have shown that chronic smoldering lesions cause brain volume loss, which is more related to disability and cognitive impairment in MS patients [7,8] .
The results showed that patients with more brain volume loss in the early stages of the disease had a significantly higher risk of long-term disability progression.
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Why can smell "bring" you back to where you have been before?
Time of Update: 2022-01-09
Each cell is activated at a specific location in the environment, and these neurons collectively encode the entire area, effectively creating a spatial neural map .
Our results reveal a function for piriform cortex in spatial cognition and suggest that it is well-suited to form odour--place associations and guide olfactory-cued spatial navigation .
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American stroke expert: Chinese study significantly reduces stroke recurrence in high-risk patients
Time of Update: 2022-01-09
Copyright information -Med) and the New England Journal of Medicine (NEJM) jointly created "NEJM Frontiers in Medicine" translation, writing or commissioningTicagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA.
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Acute cerebral infarction without vascular stenosis?
Time of Update: 2022-01-09
*For reference only for medical professionals, sometimes you just need to think about it~ On the first day of 2022, we invite you to experience the fun of exploring the truth of the disease and face
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Neuron: Oxytocin "smart hand" repairs abnormal brain function connections in autism
Time of Update: 2022-01-09
After treatment with oxytocin, different imaging techniques revealed some differences in the brain changes of Cntnap2 knockout mice: MRI revealed that NAc, BNST, medial septum, and hippocampus were the brain regions with the most obvious functional changes, while pharmacology Magnetic resonance imaging found that the blood oxygen level-dependent signal enhancement of PVN was the most obvious, and the whole brain c-fos labeling revealed that the somatosensory cortex and visual cortex had the largest number of activated neurons .
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The new "exercise factor" in Nature's blood is expected to help improve cognitive impairment
Time of Update: 2022-01-09
In summary, the study revealed a new "motor factor"—clusterin improves the cognitive ability of mice by reducing inflammation in the nervous system .
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Express over 3.5 billion US dollars to develop innovative ASO therapy, AstraZeneca and Ionis reached an agreement
Time of Update: 2022-01-09
▲Ionis' new-generation LICA technology can deliver ASO to various organs and tissues of the human body by coupling ASO with different ligands (picture source: Ionis official website) In addition, Ionis also predicts that genetic ATTR-PN will become eplontersen It is expected to submit a New Drug Application (NDA) to the US FDA before the end of 2022 .
Retrieved December 29, 2021, from https:// releases/2021/astrazeneca-and-ionis-close-eplontersen-deal.
