12-year follow-up study: Chronic disease has an extraordinary impact on the brain!

▎The editing of WuXi AppTec's content team is becoming more and more common for the elderly to undergo surgery, but surgery may also be risky
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Among them, postoperative cognitive decline (POCD) is a common risk that may occur in the elderly after surgery, mainly manifested as impaired memory and attention, which may be temporary, or may last for months or even years
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Research estimates that about one in ten elderly patients (60 years and older) may show some degree of cognitive dysfunction within three months after surgery
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At present, the diagnostic criteria for postoperative cognitive decline have not been standardized, and the reasons and risk factors are also being explored
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Image source: 123RF Recently, a study shared at the annual meeting of the European Society of Anesthesiology and Intensive Care (ESAIC) showed that for patients with high blood pressure, type 2 diabetes or low education, their long-term recognition The degree of cognitive decline may be more serious than that of patients undergoing general anesthesia
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Researchers from the Netherlands analyzed 1823 participants with an average age of 51 years.
These participants had normal cognitive functions at the beginning of the study
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In order to observe the cognitive development of the participants, the researchers followed up with the participants in the 6th and 12th years.
During the follow-up, the researchers tested each participant
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Each test includes a physical examination and a series of cognitive function tests
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The cognitive function test mainly analyzes the participants' learning and memory, executive ability, information processing speed, and selective attention
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After modeling analysis, it was found that compared with patients who had never received general anesthesia, patients who had received more than two general anesthesia operations at the beginning of the study were often older and had other health conditions, such as high blood pressure and coronary artery disease, high cholesterol and so on
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After adjusting for age, gender, education level, smoking status, alcoholism and other factors related to the risk of cognitive decline, the researchers found that compared with people who have never undergone surgery, they have had at least one type of general anesthesia Of patients may perform worse on selective attention, executive ability, and selective attention tests
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In addition, the researchers also found that although the amount of general anesthetics does not seem to affect cognitive function and performance, for patients with high blood pressure, hypercholesterolemia, type 2 diabetes, a history of smoking, or a low level of education , Long-term cognitive ability is much more affected than general anesthesia
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Specifically, for patients with hypertension, hypercholesterolemia, and type 2 diabetes, their selective attention, mental speed, and information processing speed have a significant impact; for participants with lower education levels, Long-term cognitive ability will be significantly affected
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Image source: 123RF The lead author of the study, Dr.
Christoph Pennings of Maastricht University (Maastricht University) explained: “There is a natural process of cognitive decline throughout our lives, so after 12 years, almost Everyone in the study will experience some form of cognitive decline
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Different people have different ways and speeds, such as sudden, gradual, slow and gentle
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" "Our research shows that under general anesthesia more than Patients undergoing one operation have almost no effect on long-term cognitive decline, but there are subtle impairments in information processing ability, selective attention, execution, and mental speed
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On the
contrary, history of hypertension, diabetes, and Factors such as education level seem to have a greater impact on the speed of our cognitive decline
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"The author also pointed out the limitations of the study, including limited information about the duration and type of surgery, limited specific information about the type and depth of anesthesia, and changes in surgery and anesthesia techniques over time, which may affect the results of the study.

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Related reading after surgery to reduce the common delirium, local anesthesia or general anesthesia warm attached to two studies led boarded JAMA "lancet":?? children anesthesia affects brain development by far the most compelling evidence yet published in BMJ: 60 years to answer questions! Will brain function really decline after surgery? Fish oil supplementation may improve cognitive function! According to the latest AHA report, this ingredient is “indispensable” and the Peking University team’s new discovery: improving depression may slow the decline of cognitive function | Source: 123RF reference materials [1] General anaesthesia impacts brain functioning less than other patient risk factors, data spanning 12 years suggests.
Retrieved DECEMBER 18, 2021, FROM https://medicalxpress.
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