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Break through the traditional treatment!
Time of Update: 2022-01-09
The results of PARAMETER study 5 showed that sacubitril and valsartan treatment for 12 weeks can significantly reduce the 24-hour average brachial and aortic systolic blood pressure (SBP), which is better than angiotensin receptor antagonist (ARB), especially night blood pressure The decrease is more obvious (Figure 1) .
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Courier treatment of "gradual freezing syndrome", innovative treatments are eligible for priority review
Time of Update: 2022-01-09
▎The content team editor of WuXi AppTec recently announced that Amylyx Pharmaceuticals announced that the US FDA has accepted the New Drug Application (NDA) of AMX0035 for the treatment of amyotrophic lateral sclerosis (ALS) and granted priority review status .
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Why did the research of CHANCE-2 that top NEJM make a global sensation?
Time of Update: 2022-01-09
On October 28, 2021, the New England Journal of Medicine (NEJM) published online CHANCE-2 research results of Professor Wang Yongjun's team, Dean of Beijing Tiantan Hospital Affiliated to Capital Medical University and Deputy Director of the National Neurological Diseases Clinical Medicine Research Center.
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Anshiping®-the first and only drug with indications for the treatment of NMOSD landed for the first time in China, creating a new era of NMOSD treatment
Time of Update: 2022-01-09
This year, the ECTRIMS conference published an extended phase study 3 to evaluate the long-term efficacy of satrizizumab in AQP4-IgG-positive patients from the SAkura study .
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Nat Neurosci│Cao Peng's laboratory discovered the important function of pain in the struggle for survival between species
Time of Update: 2022-01-09
In order to reveal the connection between vGAT+ AHN neurons and noxious mechanical stimuli, the authors used a calcium imaging optical fiber recording system and injected them into the AHN brain area of vGAT-IRES-Cre mice.
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Neuron "Love and Hate"-the neural matrix of women's social behavior with changes in their physiological state
Time of Update: 2022-01-09
This social decision depends on the female's current breastfeeding physiological state: for non-lactating females, male mice are potential partners .
The authors used calcium ion imaging to track and record the responses of alpha and beta neurons of the same female to the same male odor signal in virgin, lactation and post-weaning physiological states, respectively .
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The last tweet in 2021: May there be no stress and anxiety in 2022!
Time of Update: 2022-01-09
Figure 1: Social stress activates vCA3-COCH neurons after continuous attacks in mice cause anxiety-like behaviors, and vCA3-COCH neurons are activated in large numbers (Figure 1) .
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The Plant Journal Professor Nan Yao's team from Sun Yat-sen University reveals the molecular mechanism of ceramide regulating plant resistance
Time of Update: 2022-01-09
In vivo and in vitro enzyme activity experiments proved that ceramide can promote the activity of RbohD, indicating that ceramide mediates the regulation of plant resistance through RbohD .
This study proved for the first time that ceramide can directly bind to RbohD and promote its activity.
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Loss of sensation on the left side of the face and the opposite limb...Can you make a decision within 3 seconds after seeing the film?
Time of Update: 2022-01-09
The lateral dorsal medulla syndrome is caused by the occlusion of the posterior inferior cerebellar artery and the lateral medulla oblongata infarction .
The dorsolateral medulla syndrome is usually caused by the occlusion of the posterior inferior cerebellar artery and the dorsolateral medulla oblongata infarction .
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Should not be missed!
Time of Update: 2022-01-09
The FDA has approved brivaracetam (Briviact; UCB Pharma) CV tablets and oral solution for extended indications, which is a drug for the treatment of children with partial seizures .
Efgartigimod is a pioneering targeted therapy drug, and its approval provides a new treatment option for patients with rare diseases .
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Can the use of allopurinol after stroke reduce the progression of white matter hyperintensity?
Time of Update: 2022-01-09
Based on the above findings, the researchers conducted a study on whether allopurinol can reduce WMH progression (a marker of stroke risk) and blood pressure after ischemic stroke or TIA .
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Investment trend Xinxu completes Series C financing to promote the development and commercialization of diagnostic and therapeutic drugs for neurodegenerative diseases
Time of Update: 2022-01-09
Accelerate the development of Xinxu's diagnostic and therapeutic drugs for neurodegenerative diseases, and meet the momentum of global pharmaceutical companies aiming at the development of drugs for the diagnosis and treatment of Alzheimer's disease .
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Express Aiming at novel targets, Ovid/AstraZeneca cooperate to develop epilepsy therapy
Time of Update: 2022-01-09
▎Editor of WuXi AppTec content team On January 3, 2022, Ovid Therapeutics announced that it has reached an exclusive license agreement with AstraZeneca to obtain AstraZeneca’s early development stage small molecule library targeting KCC2 transporters (including Lead drug candidate OV350) .
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Can Alzheimer's disease be prevented 25 years in advance?
Time of Update: 2022-01-09
The world’s top medical journal "The Lancet" launched a Seminar article this year specifically for Alzheimer’s disease, sorting out important medical advances in this field in recent years, covering content from clinical manifestations, pathology, genetic factors, to Biomarkers for diagnostic testing, as well as the positive effects of disease mitigation treatments and life>.
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[Research] Mental decline is inevitable, and language and music will ease it!
Time of Update: 2022-01-09
In order to combat this decline and prevent the pathological changes in brain aging, studies have analyzed the effects of music in building cognition and brain reserve, showing that high levels of cognitive reserve can help prevent dementia, Parkinson’s disease or multiple sclerosis Lasts for several years .
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Exploration Mitochondrial Targeting Nanoparticles to Treat Neurodegenerative Diseases
Time of Update: 2022-01-09
Recently, Exploration published a review paper "Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases" written by Professor Chang Jin from the School of Life Sciences of Tianjin University .
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Nature Neuroscience: New Year's first release!
Time of Update: 2022-01-09
Further light activation of inhibitory neurons in the AHN brain region can enhance the defensive behavior of the plastic snake biting plastic snakes caused by mechanical stimulation.
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Guidance and consensus not to be missed in neurology in 2021 year-end inventory
Time of Update: 2022-01-09
Recommended reading: 2021 Emergency Diagnosis and Treatment Guidelines for Vertigo Released, 3 minutes speed reading 11 Perforator atherosclerosis Chinese expert consensus Perforator atherosclerosis (BAD) is a common type of acute ischemic stroke, stroke in China The Society of Cerebral Small Vascular Disease Branch established an expert group, combined with the current research status at home and abroad, to write this expert consensus to guide the clinical diagnosis and treatment of BAD .
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Diagnosis and treatment of stroke, see what the expert consensus says?
Time of Update: 2022-01-09
(4) Patients with thrombolysis and thrombectomy in other acute phases of ischemic stroke should be closely monitored for changes in their condition, and the National Institutes of Health Stroke Scale (NIHSS) score should be performed according to the time node.
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The higher the education level, the slower the brain degeneration!
Time of Update: 2022-01-09
A recent study by the University of Zurich showed that older people with a high level of education have significantly fewer signs of degeneration in the brain .
