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As the main component of the cell membrane system, sphingolipids participate in the regulation of many cell biological processes
.
Ceramide is the core molecule of sphingolipid metabolism pathway and plays a key role in the process of sphingolipid-mediated signal transduction
.
However, the key target protein downstream of ceramide is still unclear
.
Recently, the team of Professor Nan Yao from the School of Life Sciences of Sun Yat-sen University published a research paper entitled Ceramides regulate defense response by binding to RbohD in Arabidopsis online in The Plant Journal, revealing the mechanism of ceramides regulating defense response by binding to RbohD in Arabidopsis
.
The study found that mutating the ceramidase gene ACER in the Arabidopsis ceramide kinase mutant acd5 background, the obtained double mutant acer acd5 showed a specific high accumulation of ceramide, while other sphingolipid components were similar to wild-type plants.
Compared with no significant change
.
At the same time, the salicylic acid (SA) and reactive oxygen species (ROS) signals in acer acd5 are continuously activated
.
By observing the location of ROS production in acer acd5 cells, it is found that the plasma membrane is the main location of ROS production
.
By expressing RbohD protein in vitro and performing protein-lipid binding experiments, it was found that ceramide can directly bind to RbohD
.
In vivo and in vitro enzyme activity experiments proved that ceramide can promote the activity of RbohD, indicating that ceramide mediates the regulation of plant resistance through RbohD
.
Figure 1.
Ceramide binds to RbohD and promotes its enzyme activity.
This study proved for the first time that ceramide can directly bind to RbohD and promote its activity.
It clarified the downstream target protein of ceramide and provided a new idea for elucidating the biological functions of plant sphingolipids
.
The research was funded by the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province
.
This article is reproduced from the Plant Biology Plant Biotechnology Pbj Exchange Group.
In order to more effectively help the majority of scientific researchers to obtain relevant information, the Plant Biotechnology Pbj has established a WeChat group, Plant Biotechnology Journal submissions and document-related issues, public account release content and The public account submission questions will be concentrated in the group for answers, and at the same time, academic exchanges and collision thinking in the group are encouraged
.
In order to ensure a good discussion environment in the group, please add the editor WeChat first, scan the QR code to add, and then we will promptly invite you to join the group
.
Tips: When adding the editor's WeChat and after joining the group, please note the school or unit + name.
Please indicate the PI at the end and we will invite you to join the PI group
.
.
Ceramide is the core molecule of sphingolipid metabolism pathway and plays a key role in the process of sphingolipid-mediated signal transduction
.
However, the key target protein downstream of ceramide is still unclear
.
Recently, the team of Professor Nan Yao from the School of Life Sciences of Sun Yat-sen University published a research paper entitled Ceramides regulate defense response by binding to RbohD in Arabidopsis online in The Plant Journal, revealing the mechanism of ceramides regulating defense response by binding to RbohD in Arabidopsis
.
The study found that mutating the ceramidase gene ACER in the Arabidopsis ceramide kinase mutant acd5 background, the obtained double mutant acer acd5 showed a specific high accumulation of ceramide, while other sphingolipid components were similar to wild-type plants.
Compared with no significant change
.
At the same time, the salicylic acid (SA) and reactive oxygen species (ROS) signals in acer acd5 are continuously activated
.
By observing the location of ROS production in acer acd5 cells, it is found that the plasma membrane is the main location of ROS production
.
By expressing RbohD protein in vitro and performing protein-lipid binding experiments, it was found that ceramide can directly bind to RbohD
.
In vivo and in vitro enzyme activity experiments proved that ceramide can promote the activity of RbohD, indicating that ceramide mediates the regulation of plant resistance through RbohD
.
Figure 1.
Ceramide binds to RbohD and promotes its enzyme activity.
This study proved for the first time that ceramide can directly bind to RbohD and promote its activity.
It clarified the downstream target protein of ceramide and provided a new idea for elucidating the biological functions of plant sphingolipids
.
The research was funded by the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province
.
This article is reproduced from the Plant Biology Plant Biotechnology Pbj Exchange Group.
In order to more effectively help the majority of scientific researchers to obtain relevant information, the Plant Biotechnology Pbj has established a WeChat group, Plant Biotechnology Journal submissions and document-related issues, public account release content and The public account submission questions will be concentrated in the group for answers, and at the same time, academic exchanges and collision thinking in the group are encouraged
.
In order to ensure a good discussion environment in the group, please add the editor WeChat first, scan the QR code to add, and then we will promptly invite you to join the group
.
Tips: When adding the editor's WeChat and after joining the group, please note the school or unit + name.
Please indicate the PI at the end and we will invite you to join the PI group
.
