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Neurodegenerative diseases (NDs) are a series of diseases of acquired progressive cognitive impairment.
The common ones are Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (Huntington's disease, HD), and amyotrophic lateral sclerosis (amyotrophic lateral sclerosis, ALS) and the like
.
This type of disease can lead to increased levels of oxidative stress in the brain and increased accumulation of mitochondrial DNA (mtDNA) mutations, which in turn triggers mitochondrial dysfunction and aggravates the pathological process of NDs
.
The role of mitochondrial dysfunction in NDs has become a hot research topic, and it is expected to provide potential targets for the treatment of NDs
.
In view of the many advantages of nanoparticles, they have become an effective strategy for the treatment of NDs
.
Due to its adjustable particle size, easy modification of the surface, and large specific surface area, it can increase the circulation time of the drug in the body, the targeting efficiency of the lesion site, and increase the bioavailability and safety of the drug
.
Recently, Exploration published a review paper "Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases" written by Professor Chang Jin from the School of Life Sciences of Tianjin University
.
The author introduced different types of nanoparticles that can be used to treat NDs related to mitochondrial dysfunction
.
In this review, the author first briefly introduced the structure and function of mitochondria, and discussed the relationship between mitochondrial dysfunction and the pathogenesis of the four NDs
.
Secondly, the obstacles and strategies for targeting neuronal mitochondria are discussed and summarized: including physiological barriers that prevent nanoparticles from targeting neuronal mitochondria (such as blood-brain barrier, cell membrane and mitochondrial membrane), as well as some penetration of the above-mentioned barriers Among the existing strategies, nanotechnology stands out among many strategies
.
Third, it introduces nanoparticles designed based on the characteristics of physiological barriers for mitochondrial targeted diagnosis or treatment, and introduces three categories of organic nanoparticles, inorganic nanoparticles and biofilm-encapsulated nanoparticles in detail
.
For example, considering that the mitochondrial membrane is rich in cardiolipin, liposomes and polymer nanoparticles are synthesized; based on the strong negative potential (ΔΨm) of the mitochondrial inner membrane, cationic molecules, such as DQA and TPP, are synthesized; targeted modification on the surface of the nanoparticles Peptides, such as blood-brain barrier penetration and neuron targeting peptides, enhance the blood-brain barrier penetration and neuron targeting of nanoparticles
.
More importantly, the surface of nanoparticles can be modified with many different types of targeting molecules to form a dual targeting system for neurons and mitochondria
.
Finally, the application prospects of mitochondrial targeted nanotherapy in the treatment of NDs and the problems to be solved are discussed, and further research is needed to develop the best treatment methods for NDs related to mitochondrial dysfunction based on nanotechnology
.
The first author of this article is Zhang Yue, a postgraduate student in the School of Life Sciences, Tianjin University, and the corresponding authors are Professor Chang Jin and Associate Professor Wu Xiaoli from the School of Life Sciences, Tianjin University
.
A brief introduction to the corresponding author: Professor Chang Jin, an expert enjoying special government allowances from the State Council, a talented professor and doctoral supervisor of Tianjin University
.
The current director of the Institute of Nanobiomedicine, Tianjin University College of Student Sciences, the director of Tianjin Micro-nano Biomaterials and Inspection and Therapy Engineering Technology Center, the chairman of Tianjin Biomedical Engineering Society, the vice chairman of Chinese Particle Society, and the nanomedicine of Chinese Biomedical Engineering Society With the chairman of the engineering branch
.
For many years, he has mainly engaged in the basic and applied research of nano-biomedical materials and technologies in the diagnosis and treatment of major diseases such as tumors and Alzheimer's
.
Has undertaken more than 50 national key research and development programs, 863 key projects, and the National Natural Science Foundation of China.
They have been published in Sci.
Adv.
, Adv.
Mater.
, Nano Today, Adv.
Funct.
Mater.
, Adv.
Sci.
, ACS.
Nano.
and other domestic and foreign journals have published more than 350 academic papers, including 235 SCI papers, 88 JCR articles, 42 papers with IF>10, and a cumulative SCI impact factor (IF)>1600
.
Applied for more than 120 invention patents in the United States and China, obtained more than 40 authorized invention patents, and transferred 12 patents; edited and participated in the compilation of 3 academic monographs at home and abroad; won 1 first prize of Tianjin Natural Science Award, Tianjin Science and Technology Progress 1 3 prizes, and was awarded the title of "National Outstanding Scientific and Technological Worker" by the China Association for Science and Technology
.
Scan the QR code on the left to read the original text.
The content of this article is based on the "Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases" published in the Review Article of the Wiley Publishing Group's cooperative journal Exploration Volume I and Issue III DOI: 10.
1002/EXP.
20210115 Citation format: Y .
Zhang, H.
Yang, D.
Wei, X.
Zhang, J.
Wang, X.
Wu, J.
Chang, Exploration 2021, 1, 20210115.
https://doi.
org/10.
1002/EXP.
20210115ENDAdvancedScienceNewsWiley's research information On the official WeChat platform, long press the QR code to follow us to share cutting-edge information｜Focus on scientific research trends, publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
The common ones are Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (Huntington's disease, HD), and amyotrophic lateral sclerosis (amyotrophic lateral sclerosis, ALS) and the like
.
This type of disease can lead to increased levels of oxidative stress in the brain and increased accumulation of mitochondrial DNA (mtDNA) mutations, which in turn triggers mitochondrial dysfunction and aggravates the pathological process of NDs
.
The role of mitochondrial dysfunction in NDs has become a hot research topic, and it is expected to provide potential targets for the treatment of NDs
.
In view of the many advantages of nanoparticles, they have become an effective strategy for the treatment of NDs
.
Due to its adjustable particle size, easy modification of the surface, and large specific surface area, it can increase the circulation time of the drug in the body, the targeting efficiency of the lesion site, and increase the bioavailability and safety of the drug
.
Recently, Exploration published a review paper "Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases" written by Professor Chang Jin from the School of Life Sciences of Tianjin University
.
The author introduced different types of nanoparticles that can be used to treat NDs related to mitochondrial dysfunction
.
In this review, the author first briefly introduced the structure and function of mitochondria, and discussed the relationship between mitochondrial dysfunction and the pathogenesis of the four NDs
.
Secondly, the obstacles and strategies for targeting neuronal mitochondria are discussed and summarized: including physiological barriers that prevent nanoparticles from targeting neuronal mitochondria (such as blood-brain barrier, cell membrane and mitochondrial membrane), as well as some penetration of the above-mentioned barriers Among the existing strategies, nanotechnology stands out among many strategies
.
Third, it introduces nanoparticles designed based on the characteristics of physiological barriers for mitochondrial targeted diagnosis or treatment, and introduces three categories of organic nanoparticles, inorganic nanoparticles and biofilm-encapsulated nanoparticles in detail
.
For example, considering that the mitochondrial membrane is rich in cardiolipin, liposomes and polymer nanoparticles are synthesized; based on the strong negative potential (ΔΨm) of the mitochondrial inner membrane, cationic molecules, such as DQA and TPP, are synthesized; targeted modification on the surface of the nanoparticles Peptides, such as blood-brain barrier penetration and neuron targeting peptides, enhance the blood-brain barrier penetration and neuron targeting of nanoparticles
.
More importantly, the surface of nanoparticles can be modified with many different types of targeting molecules to form a dual targeting system for neurons and mitochondria
.
Finally, the application prospects of mitochondrial targeted nanotherapy in the treatment of NDs and the problems to be solved are discussed, and further research is needed to develop the best treatment methods for NDs related to mitochondrial dysfunction based on nanotechnology
.
The first author of this article is Zhang Yue, a postgraduate student in the School of Life Sciences, Tianjin University, and the corresponding authors are Professor Chang Jin and Associate Professor Wu Xiaoli from the School of Life Sciences, Tianjin University
.
A brief introduction to the corresponding author: Professor Chang Jin, an expert enjoying special government allowances from the State Council, a talented professor and doctoral supervisor of Tianjin University
.
The current director of the Institute of Nanobiomedicine, Tianjin University College of Student Sciences, the director of Tianjin Micro-nano Biomaterials and Inspection and Therapy Engineering Technology Center, the chairman of Tianjin Biomedical Engineering Society, the vice chairman of Chinese Particle Society, and the nanomedicine of Chinese Biomedical Engineering Society With the chairman of the engineering branch
.
For many years, he has mainly engaged in the basic and applied research of nano-biomedical materials and technologies in the diagnosis and treatment of major diseases such as tumors and Alzheimer's
.
Has undertaken more than 50 national key research and development programs, 863 key projects, and the National Natural Science Foundation of China.
They have been published in Sci.
Adv.
, Adv.
Mater.
, Nano Today, Adv.
Funct.
Mater.
, Adv.
Sci.
, ACS.
Nano.
and other domestic and foreign journals have published more than 350 academic papers, including 235 SCI papers, 88 JCR articles, 42 papers with IF>10, and a cumulative SCI impact factor (IF)>1600
.
Applied for more than 120 invention patents in the United States and China, obtained more than 40 authorized invention patents, and transferred 12 patents; edited and participated in the compilation of 3 academic monographs at home and abroad; won 1 first prize of Tianjin Natural Science Award, Tianjin Science and Technology Progress 1 3 prizes, and was awarded the title of "National Outstanding Scientific and Technological Worker" by the China Association for Science and Technology
.
Scan the QR code on the left to read the original text.
The content of this article is based on the "Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases" published in the Review Article of the Wiley Publishing Group's cooperative journal Exploration Volume I and Issue III DOI: 10.
1002/EXP.
20210115 Citation format: Y .
Zhang, H.
Yang, D.
Wei, X.
Zhang, J.
Wang, X.
Wu, J.
Chang, Exploration 2021, 1, 20210115.
https://doi.
org/10.
1002/EXP.
20210115ENDAdvancedScienceNewsWiley's research information On the official WeChat platform, long press the QR code to follow us to share cutting-edge information｜Focus on scientific research trends, publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
