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    Home > Active Ingredient News > Study of Nervous System > Neurology: CT/MRI perfusion imaging identifies post-thrombectomy cerebral no-reflow and is associated with treatment complications and poor 3-month prognosis

    Neurology: CT/MRI perfusion imaging identifies post-thrombectomy cerebral no-reflow and is associated with treatment complications and poor 3-month prognosis

    • Last Update: 2022-01-21
    • Source: Internet
    • Author: User
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    In patients with acute ischemic stroke due to large vessel occlusion , a substantial proportion of patients have poor functional outcomes despite prompt and successful angiographic reperfusion .


    Tissue reperfusion has been shown to be a stronger determinant of clinical outcome than arterial recanalization



    We performed a pooled analysis of 3 prospective, international, multicenter, randomized controlled trials of thrombectomy using prespecified follow-up perfusion imaging and core laboratory-determined angiographic assessment to investigate cerebral no-reflow.



    No-reflow was defined as a persistent area of ​​hypoperfusion in the absence of carotid artery stenosis or reocclusion in the presence of relative cerebral blood flow or cerebral blood flow maps, quantitatively validated by >15% asymmetry


    • No-reflow zones were found in 33 of 130 patients (25.


      Brain no-reflow is common, can be detected by its characteristic perfusion imaging profile using clinically-available sequences, and is associated with post-treatment complications and dependence or death


      Source: Ng FC, Churilov L, Yassi N, et al.


      Ng FC, Churilov L, Yassi N, et al.
      Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow) [published online ahead of print, 2021 Dec 14].
      Neurology.
      2021;10.
      1212/WNL.
      0000000000013210 .
      doi:10.
      1212/WNL.
      0000000000013210

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