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In patients with acute ischemic stroke due to large vessel occlusion , a substantial proportion of patients have poor functional outcomes despite prompt and successful angiographic reperfusion .
Tissue reperfusion has been shown to be a stronger determinant of clinical outcome than arterial recanalization
We performed a pooled analysis of 3 prospective, international, multicenter, randomized controlled trials of thrombectomy using prespecified follow-up perfusion imaging and core laboratory-determined angiographic assessment to investigate cerebral no-reflow.
No-reflow was defined as a persistent area of hypoperfusion in the absence of carotid artery stenosis or reocclusion in the presence of relative cerebral blood flow or cerebral blood flow maps, quantitatively validated by >15% asymmetry
- No-reflow zones were found in 33 of 130 patients (25.
Brain no-reflow is common, can be detected by its characteristic perfusion imaging profile using clinically-available sequences, and is associated with post-treatment complications and dependence or deathSource: Ng FC, Churilov L, Yassi N, et al.
Ng FC, Churilov L, Yassi N, et al.
Prevalence and Significance of Impaired Microvascular Tissue Reperfusion Despite Macrovascular Angiographic Reperfusion (No-Reflow) [published online ahead of print, 2021 Dec 14].
Neurology.
2021;10.
1212/WNL.
0000000000013210 .
doi:10.
1212/WNL.
0000000000013210
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