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Stroke is the leading cause of disability and death in adults worldwide
.
Identifying risk factors for stroke is important for developing effective primary and secondary prevention strategies
The development of effective anti-inflammatory therapeutic pathways to prevent stroke will require identification of key inflammatory mediators associated with stroke pathogenesis
.
While there is extensive literature showing the association of C-reactive protein (CRP) levels, a general marker of inflammation, with stroke, data on other inflammatory cytokines are limited
The development of effective anti-inflammatory therapeutic pathways to prevent stroke will require identification of key inflammatory mediators associated with stroke pathogenesis
We conducted a systematic review and meta-analysis using pooled data from the published literature and unpublished cohort studies to explore the association of circulating IL-6 levels with the risk of ischemic stroke in a population-based prospective cohort study
Following Prisma guidelines, we systematically screened the PubMed search engine, from inception to March 2021, to conduct a population-based prospective cohort study to explore the relationship between circulating IL-6 levels and the risk of ischemic stroke
.
Combined association estimates for ischemic stroke risk with random-effects models and explored non-linear effects in dose-response meta-analyses
Following Prisma guidelines, we systematically screened the PubMed search engine, from inception to March 2021, to conduct a population-based prospective cohort study to explore the relationship between circulating IL-6 levels and the risk of ischemic stroke
- Eleven studies (27,411; 2,669 stroke events) were identified as meeting the inclusion criteria
. - The average age was 60.
5 years, and 54.
8% were women
.
Overall, the quality of included studies was high (median 8/9, interquartile range 7 to 9)
- The results also remained stable after adjusting for publication bias
- The results also remained stable after adjusting for publication bias
.
There was only modest heterogeneity among studies limited to low risk of bias and studies that fully adjusted for demographic and vascular risk factors, and the results of sensitivity analyses were consistent
.
Among community residents, higher circulating IL-6 levels were linearly associated with higher long-term risk of developing ischemic stroke, independent of traditional vascular risk factors
.
Combined with findings from genetic studies and clinical trials, these results provide additional support for the critical role of IL-6 signaling in ischemic stroke
Among community residents, higher circulating IL-6 levels were linearly associated with higher long-term risk of developing ischemic stroke, independent of traditional vascular risk factors
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