Frontiers: Associations between dementia-related markers and physical activity in cognitively normal older adults

Previous studies have shown that exercise can improve cognitive function, especially in older adults
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Compared with those who did not exercise, older adults who exercised regularly had higher levels of the protein that is critical to their brain health

These differences were evident even in those whose brains showed signs of possible dementia, suggesting that exercise can slow the progression of cognitive decline

However, the underlying mechanisms of how physical activity reduces Alzheimer's disease (AD) risk are not fully understood
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To this end, experts from the School of Medicine and Health Sciences, Edith Cowan University, Australia, conducted a study to assess habitual physical activity levels and brain amyloid deposition in APOE ε4 carriers and non-carriers, as well as AD-related blood Relationships between biomarkers (measured using a novel high-performance mass spectrometry method)

The study evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposits assessed using positron emission tomography (PET/CT) and their levels measured using the International Physical Activity Questionnaire (IPAQ).
Physical activity level
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The results showed an inverse correlation between brain amyloidosis and plasma Aβ1-42, but no association was found between brain amyloidosis and plasma Aβ1-40 and APP669-711
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Furthermore, higher levels of physical activity were associated with lower plasma levels of Aβ1-40, Aβ1-42 and APP669-711 in APOE ε4 non-carriers

Furthermore, higher levels of physical activity were associated with lower plasma levels of Aβ1-40, Aβ1-42 and APP669-711 in APOE ε4 non-carriers

Increased mean physical activity in later life is associated with higher synaptic proteins in brain tissue at death

Further analysis revealed that the ratios of Aβ1-40/Aβ1-42 and APP669-711/Aβ1-42, which were associated with higher brain amyloidosis in previous studies, differed between APOE ε4 carriers and non-carriers
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Further analysis revealed that the ratios of Aβ1-40/Aβ1-42 and APP669-711/Aβ1-42, which were associated with higher brain amyloidosis in previous studies, differed between APOE ε4 carriers and non-carriers
.

Further analysis revealed that the ratios of Aβ1-40/Aβ1-42 and APP669-711/Aβ1-42, which were associated with higher brain amyloidosis in previous studies, differed between APOE ε4 carriers and non-carriers

These data demonstrate a complex relationship between physical activity and brain amyloid deposition and potential blood-based biomarkers of AD in cognitively normal older adults

references:

The association between Alzheimer's disease related markers and physical activity in cognitively normal older adults.

The association between Alzheimer's disease related markers and physical activity in cognitively normal older adults.
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