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Childhood obesity increases risk of type 1 diabetes
Time of Update: 2022-05-11
The researchers analysed human genetic data from 454,023 individuals from the UK Biobank and 15,573 cases of type 1 diabetes from other cohorts, and applied a scientific technique called Mendelian randomisation (MR) to provide evidence that children Obesity increases the risk of type 1 diabetes .
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Zhou Yue's group published a paper in The Plant Cell to reveal the chromatin remodeling complex..
Time of Update: 2022-05-11
On April 22, 2022 , Zhou Yue's research group from the State Key Laboratory of Protein and Plant Gene Research, the School of Modern Agriculture of Peking University, and the Peking University-Tsinghua University Life Science Joint Center published an online article entitled "Chromatin remodeling complexes" on The Plant Cell .
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Biochemical research in Rao Yi's lab: separation and purification of protein kinases revealing AMPK and its related kinases
Time of Update: 2022-05-11
Since 2016, Liu Yuxiang (postgraduate/postdoc), Wang Tao (postgraduate), Cui Yunfeng (technician), Li Chaoyi (postdoctoral), Jiang Lifen (postdoctoral), Rao Yi through in vitro biochemical prompts, a dozen or twenty STE20 protein kinases Phosphorylates AMPK and SIK3 .
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$2.3 million: Identifying metabolic vulnerabilities in ovarian cancer to develop potential treatments
Time of Update: 2022-05-11
Previous research led by Woo found that higher expression of apelin and APJ in the tumor microenvironment caused ovarian cancer cells to increase the use of lipids for energy, thereby improving cell survival, fitness and proliferation .
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New study finds genetic changes in esophageal cancer patients
Time of Update: 2022-05-11
"While the team's ultimate goal is to improve esophageal cancer diagnosis and screening, Paulson emphasized that the study compared the mutations and DNA changes that occurred in patients who progressed to the cancer with those that occurred in patients with stable benign BE .
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FDA Fast Track Designation for Innovative Cell Therapy for HPV16-Positive Solid Tumors
Time of Update: 2022-05-11
S. Food and Drug Administration (FDA) granted Fast Track designation to its lead cell therapy candidate SQZ-PBMC-HPV for the treatment of patients with human papillomavirus (HPV) 16-positive advanced or metastatic solid tumors .
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Improved silver coating on medical devices prevents infection
Time of Update: 2022-05-11
In a study in ACS Central Science, a team describes a new, long-lasting silver ion-releasing coating that, in mice, prevents bacteria from attaching to implants and then kills them .
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Next-Generation Anti-CTLA-4 mAb Receives FDA Fast Track Designation for the Treatment of Non-Small Cell Lung Cancer
Time of Update: 2022-05-11
Currently, ONC-392 is undergoing a Phase 1 clinical study overseas (PRESERVE-001 study) to evaluate its safety, pharmacokinetics, and efficacy as monotherapy and in combination with anti-PD-1 standard therapy in advanced solid tumors and NSCLC.
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Guangzhou Health Center has made new progress in the construction and application of primary liver cancer model
Time of Update: 2022-05-11
Recently, researcher Li Peng and Li Yinxiong of Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences published their research results on EMBO Reports entitled Transforming primary human hepatocytes to hepatocellular carcinoma with genetically defined factors , using primary human hepatocytes to induce primary hepatocytes in vivo.
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Gene mutation that causes head and neck cancer could serve as precise therapeutic target
Time of Update: 2022-05-11
"Before the era of genomic medicine, when scientists began to identify and target specific genetic mutations, "drugs of the non-precision MAPK pathway for head and neck cancer and other cancers were futile," and often "failed" in clinical trials, He and her colleagues wrote .
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Anesthetics can greatly divert the propagation of brain waves
Time of Update: 2022-05-11
"The study's lead author Sayak Bhattacharya, a Picower postdoctoral researcher in Miller's lab, reanalyzed a dataset of two animals after receiving propofol anesthesia, where they remained in this state for a period of time and then recovered awareness .
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Looking at the current situation and future of innovative drug talents
Time of Update: 2022-05-11
In this context, Tongdao Medical, together with well-known media in the industry, Shenlanguan, E-pharmaceutical managers and other 30+ industry vertical media, founders/scientists of leading innovation companies, Shanghai Free Trade One Life Science and Technology Industrial Park, star investment institutions, China The "2022 Medical Professional Promotion Season" series of activities jointly organized by the Human Resources Association of the Big Health Industry and others .
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Cancer 'stemness' regulator
Time of Update: 2022-05-11
"If you use inhibitors to this pathway, the cancer stem cells will die instead of regenerating the tumor," said Matei, who is also a professor of medicine in the Division of Hematology and Oncology .
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Biochemical research in Rao Yi's laboratory: separation and purification of proteins revealing AMPK and its related kinases..
Time of Update: 2022-05-11
Since 2016, Liu Yuxiang (postgraduate/postdoc), Wang Tao (postgraduate), Cui Yunfeng (technician), Li Chaoyi (postdoctoral), Jiang Lifen (postdoctoral), Rao Yi through in vitro biochemical prompts, a dozen or twenty STE20 protein kinases Phosphorylates AMPK and SIK3 .
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Science: Using CRISPR to build a melanoma model from scratch
Time of Update: 2022-05-11
The work is the first time scientists have used precisely controlled genetic engineering to create a human cancer model from fully differentiated or specialized cells, rather than stem cells, said Eran Hodis, first author and one of the corresponding authors of the study .
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Cell Research: Neuroprotective Small Molecule Agonists of NAD Biosynthetic Enzymes
Time of Update: 2022-05-11
Recently, the team of Wang Gelin and Tang Yefeng from the School of Pharmacy, Tsinghua University, aimed at the major needs in the field of population and health, targeting NAD metabolism regulation and neurodegeneration and other aging-related diseases, a new scientific frontier hotspot, through high-throughput drug screening and target structure-based analysis.
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A joint study by Meng Xia's research group in our hospital found that being close to green space can reduce the risk of premature birth
Time of Update: 2022-05-11
(Contributed by: Zhang Lina)Recently, the research group of Professor Kan Haidong and Meng Xia Youth Associate Researcher from the School of Public Health of Fudan University, together with the research team of Researcher Ma Xu and Associate Researcher He Yuan of the Institute of Science and Technology of the National Health and Health Commission, based on the national birth cohort, found that the increase of green space around the living environment of the research subjects was associated with premature birth.
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Revisiting neuroscientific hypotheses—new mechanisms of learning
Time of Update: 2022-05-11
New demonstrations of efficient learning of dendritic trees require new approaches to brain research and the generation of corresponding hardware aimed at implementing advanced artificial intelligence algorithms .
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Academician Kang Le: A new mechanism of piRNAs regulation determines changes in the number of offspring of migratory locusts
Time of Update: 2022-05-11
This study also suggests that the novel mechanism of Piwi/piRNAs-mediated mRNA splicing of coding genes found in migratory locusts may also be common in other animals to regulate reproductive strategies .
The regulatory mechanism of Piwi/piRNAs-mediated pre-mRNA splicing on reproductive function-related genes was revealed .
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Scientists discover a new mechanism that regulates the elasticity of the heart muscle
Time of Update: 2022-05-11
The study, published in Redox Biology, builds on earlier observations showing that oxidation of the amino acid cysteine modulates the in vitro mechanical properties of carnosine .
This group of conserved cysteines is observed to modulate the mechanical properties of carnosine in vitro .
