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Researchers identify brain region linked to satiety
Time of Update: 2022-03-08
A new University of Arizona-led study published in the journal Molecular Metabolism has uncovered a brain region and neural circuit that regulates satiety, which could help scientists better target drugs for eating disorders or weight management .
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"PNAS" New Perspectives on Cancer Metastasis Research
Time of Update: 2022-03-08
Kshitiz, assistant professor in the Department of Biomedical Engineering, discovered regulatory sequences in the genomes of mammals, including cows, pigs, horses, and humans, that explain how the endometrium is invaded by the placenta, and how normal How tissue is invaded by cancer .
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Peking University Dentistry Professor Deng Xuliang's team and collaborators published innovative research results on artificial tooth enamel in the journal "Science"
Time of Update: 2022-03-08
This research work provides a new engineering design method and approach for the macro-assembly of artificial tooth enamel to perfectly replicate the multi-scale hierarchical structure of natural biomaterials.
The multi-level enamel-like composites prepared in this study achieved high stiffness (105GPa), high hardness (5.
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Rottecept for injection is approved for marketing, bringing a new treatment option for thalassemia patients
Time of Update: 2022-03-08
Public information shows that the approval of rotacept for injection will bring a new treatment option for adult patients with β-thalassemia, which is expected to reduce the burden of blood transfusion in patients with transfusion-dependent β-thalassemia and reduce the iron overload caused by blood transfusion.
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"Nature": Qiu Jinlong's team of the Institute of Microbiology, Chinese Academy of Sciences uses dual "gene scissors" to achieve breakthrough disease-resistant and high-yield breeding of wheat
Time of Update: 2022-03-08
As a result, using genome editing technology to mutate the susceptible gene MLO of wheat, a material with broad-spectrum and durable resistance to powdery mildew was obtained, demonstrating the huge application potential of genome editing in crop breeding with complex genomes .
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The research team of Jiaotong University and Fudan University cooperates to realize the ultrafast pumping of nuclear homogeneous states by laser plasma
Time of Update: 2022-03-08
This work is the first experimental verification of the ultrafast excitation of short-lived nuclear isomers, thus opening up a new nuclear excitation method called laser "plasma exciter", which can be widely used in various nuclear excitation and nucleosynthesis research with application .
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Wuhan Botanical Garden has made new progress in the study of the phylogenetic evolution of Polygonatum
Time of Update: 2022-03-08
Recently, researcher Qiu Yingxiong of the East Asian Plant Evolution , Conservation and Utilization Subject Group of Wuhan Botanical Garden published the title "Out of the Himalaya-Hengduan Mountains: Phylogenomics, biogeography and diversification of Polygonatum Mill .
0000pt;">Fig. 1 The phylogenetic tree (left), differentiation time and ancestral distribution area reconstruction of Polygonatum based on 78 chloroplast protein-coding genes (right)0000pt;mso-font-kerning:1.
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Ji Guangju's group reveals the important role of ERp44 in the development of mouse cardiac intimal cushion
Time of Update: 2022-03-08
On January 28, 2022, the research group of Ji Guangju from the Institute of Biophysics, Chinese Academy of Sciences published a research result entitled "ERp44 is required for endocardial cushion development by regulating VEGFA secretion in myocardium" online in " Cell Proliferation " .
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Identifying a unique 'switch' for angiogenesis
Time of Update: 2022-03-08
By systematically analyzing epigenetic changes in vascular endothelial cells stimulated by angiogenesis, Professor Takashi Minami (Kumamoto University, Japan) and his team discovered a unique epigenetic modification (bivalent histone mark switch ), a key transcription factor specific for genes necessary for the induction of angiogenesis, and revealed that histone modifications responsible for this modification are critical for postnatal angiogenesis .
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Mutation 'hot spots' reveal new cancer-inducing factors
Time of Update: 2022-03-08
The researchers found that "cluster of somatic mutations" induced cancer progression in about 10 percent of people, and understanding them could predict patient survival .
The researchers also identified various factors that lead to cluster somatic mutations .
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India's new vaccine can fight six coronaviruses
Time of Update: 2022-03-08
"In this study, we used an immunoinformatics approach to design 'AbhiSCoVac', a multi-epitope, multi-target chimeric peptide that can Protective immunity against 6 strongly pathogenic members of the coronavirus family, including 2019-nCoV, SARS-CoV and MERS-CoV .
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The repeated inhalation vaccine for the global epidemic is expected to become a powerful tool for the prevention and control of Omicron
Time of Update: 2022-03-08
The level of antibodies will gradually decline, which means that the immune effect of the vaccine will be weakened, and the new characteristics (high immune escape, infection of the upper respiratory tract) produced by the mutation of strains such as Omicron, so after large-scale vaccination, vaccination with new crown Vaccine booster shots have become a widely promoted policy around the world .
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Shanghai Jiaotong University Deng Zixin's team reveals the catalytic cycle trajectory of dimerized non-ribosomal peptide synthases
Time of Update: 2022-03-08
Recently, the team of Professor Zixin Deng from the School of Life Science and Technology of Shanghai Jiao Tong University and the State Key Laboratory of Microbial Metabolism published in the journal Nature Communications entitled "Epimerase-embedded dimerization of non-ribosomal peptide synthases.
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A new mechanism related to learning and memory - "mental retardation protein"
Time of Update: 2022-03-08
For example, FMRP, the deletion of a protein that causes Fragile X syndrome, intellectual disability and some forms of autism, has been shown to play a key role in these brain functions, helping to regulate the synaptic connections between neurons .
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Huazhong University of Science and Technology Cell Rep reports that cholecystokinin signaling regulates instinctual escape behavior
Time of Update: 2022-03-08
On February 8, 2022, Beijing time, Gao Shangbang's research group from Huazhong University of Science and Technology published a research paper titled "Escape Steering by Cholecystokinin Peptidergic Signaling" in the journal Cell Reports, discovering the cholecystokinin receptor signaling that regulates satiety Important role in instinctual avoidance behavior .
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Qian Feng's research group from the School of Pharmacy, Tsinghua University published the latest scientific article in "Theranostics" "Macropinocytosis dextran assists the targeted delivery of drugs in KRAS-mutant pancreatic cancer"
Time of Update: 2022-03-08
70kDa dextran has the potential to better target KRAS Figure 1 70kDa Dextran has more significant KRAS targeting (A: 4kDa Dextran, B: 70kDa Dextran, C: 150kDa Dextran) Conjugation of drugs to dext
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Wang Jianwei's team from Tsinghua University School of Pharmacy has made new progress in the research direction of hematopoietic stem cell function regulation
Time of Update: 2022-03-08
1. Research background 2.
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Nature sub-journal: Researchers use sound to control mammalian cells for the first time
Time of Update: 2022-03-08
"To test whether the channel could activate other types of cells in response to ultrasound, the team used a gene therapy approach that added the gene for human TRPA1 to a specific set of neurons in the brains of living mice .
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The Yiwen research group of the Institute of Biochemistry published a paper in JACS to develop a new chemical tool to realize the real...
Time of Update: 2022-03-08
On February 10 , 2022 , Professor Yi Wen 's research group from the School of Life Sciences, Zhejiang University published a research paper titled "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells" online in the Journal of the American Chemical Society .
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The genome of the giant tiger-headed manatee has been deciphered, and the cause of human ichthyosis has also been found
Time of Update: 2022-03-08
"The most surprising result of our investigation was that we figured out why this sea giant has a bark-like skin," said Diane Le Duque from the Institute of Human Genetics at Leipzig University Hospital .
