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Stress ion channel, or antiviral way?
Time of Update: 2022-01-25
Discovery of Zika virus inhibitor TMEM120A Figure 1.
Human genome-wide overexpression screening system identified that TMEM120A can inhibit Zika virus infection; a.
Inhibition of Zika virus infection in U87MG cells (c.
By what mechanism does TMEM120A inhibit Zika virus infection?
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Scientists discover unknown new gene for 'weight loss'
Time of Update: 2022-01-25
The team behind the study came from the Twin Research and Genetic Epidemiology Unit, King's College London and the National Institutes of Health Biological Resource Centre .
By analyzing these genes and whole-genome sequencing, the team identified 202 unique genomic regions whose variation was associated with the levels of 478 different metabolites .
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Omicron could drop rapidly in US and UK
Time of Update: 2022-01-25
Health: Covid-19 is likely to peak in the UK and will reach the same level in the US, at which point cases could start to drop sharply . p>Why: The mutated virus has proven so contagious that a m
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Real-time monitoring of drug pharmacokinetics in living tumor tissue
Time of Update: 2022-01-25
We performed continuous in vivo monitoring of the concentration of the chemotherapeutic drug doxorubicin at multiple tumor sites in rodent models and demonstrated clear differences in circulation-related pharmacokinetics that may have implications for the drug's efficacy and safety make a meaningful impact .
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Do "healthy fat people" really exist?
Time of Update: 2022-01-25
A prospective cohort study published in Diabetologia in 2021, based on an analysis of data from 381,363 subjects (from the UK Biobank), showed that the MHO population had multiple clinical outcomes, including type 2 diabetes, cardiovascular disease, cardiac The risk of occurrence of aging and respiratory diseases is increasing .
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Twist Bioscience launches 96-plex library preparation kit for low-depth, high-throughput next-generation sequencing
Time of Update: 2022-01-25
Leproust, CEO and Co-Founder of Twist Bioscience, said: "The Twist 96-plex Library Prep Kit includes a robust PCR-like workflow for ultra-high-throughput library construction, allowing customers to utilize low-volume sequencing data to complete high-quality genotyping across the entire genome .
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Deadly Viagra Side Effects: Worsening Abdominal Aortic Aneurysm?
Time of Update: 2022-01-25
The study showed that sildenafil (commonly known as Viagra), a drug used to treat pulmonary hypertension and erectile dysfunction, worsened abdominal aortic aneurysms .
This study recommends that sildenafil be used with caution in patients with abdominal aortic aneurysm or in high-risk groups .
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Sleep deprivation increases brain serotonin 2a receptor responses
Time of Update: 2022-01-25
The findings suggest that stimulation caused by sleep deprivation triggers EGR3 to bind to the 5-HT2A receptor gene and initiate the production of its mRNA instructions to make more protein .
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Nature sub-journal breaks conventional wisdom: cell death process is reversible
Time of Update: 2022-01-25
Researchers at the University of Illinois describe a new method for analyzing the process of pyroptosis cell death, which is often caused by infection, leading to excess inflammation in the body and showing a process long thought to be irreversible, But in fact this can be stopped and controlled .
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Associate Professor Xiao Yuling's research group has made new progress in visual precision delivery and targeted therapy
Time of Update: 2022-01-25
Recently, the Journal of Controlled Release, an internationally renowned academic journal in the field of pharmacy, published online the new achievements made by the State Key Laboratory of Virology and the research group of Associate Professor Xiao Yuling from the School of Pharmacy, Wuhan University on the visualization of targeted drug delivery and treatment .
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Sun Fei/Zhang Chuanmao's group of Peking University has made important progress in the study of the outer ring structure of nuclear pore complexes
Time of Update: 2022-01-25
On January 11, 2022, " Protein & Cell " published online the latest achievements of Sun Fei's group from the State Key Laboratory of Biomacromolecules and Zhang Chuanmao's group from Peking University in the study of the outer ring structure of the nuclear pore complex of Xenopus laevis"8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI" .
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The team of Professor Liu Ronghou of Shanghai Jiaotong University published a review paper on the reduction of ammonia inhibition by ammonia removal from anaerobic fermentation of nitrogen-rich raw materials for biogas production
Time of Update: 2022-01-25
On January 4, 2022, the research team of Liu Ronghou, a long-term professor at the Biomass Engineering Research Center, School of Agriculture and Biology, Shanghai Jiao Tong University, published a well-known journal in the field of energy and fuel "Renewable and Sustainable Energy Reviews" (SCI, District 1, Chinese Academy of Sciences, Top Journal, The impact factor is 14.
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"Nature": Rewrite the history of the birth of "super bacteria"!
Time of Update: 2022-01-25
By comparing the number of mutations in different strains of MRSA, the research team speculates that mecC-MRSA appeared in hedgehogs about 200 years ago, long before the birth of methicillin (1959) .
These naturally secreted antibiotics acted by natural selection, resulting in the coexistence of resistant mecC-MRSA with the fungus on hedgehog skin .
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4 new cassava varieties selected by the Chinese Academy of Thermal Sciences
Time of Update: 2022-01-25
. Ye Jianqiu said that strengthening the innovative utilization of excellent cassava germplasm resources and the breeding of new varieties is of great significance to the sustainable and high-quality development of the cassava industry, the adjustment of agricultural industrial structure, the increase of potato farmers' income and the revitalization of rural areas .
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Reduce the side effects of anticancer drugs
Time of Update: 2022-01-25
If we can place a nanocrystal-based device to capture excess drug in the liver's inferior vena cava, a major blood vessel, clinicians have the potential to use Higher doses of chemotherapy to kill cancer faster without worrying about damaging healthy cells .
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"Science" How does the RNA signal of plants communicate?
Time of Update: 2022-01-24
By studying the mustard-like plant Arabidopsis thaliana, Professor David Jackson of Cold Spring Harbor Laboratory (CSHL) and his team discovered that RNA messages require a special protein to escort them where they need to go .
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New research reveals how lung's immune cells develop after birth
Time of Update: 2022-01-24
"In the first type of development, lung macrophages originate from precursor cells already present in the fetal liver," said Tim Willinger, associate professor at the Harding School of Medicine at Karolinka Institutet, who led the this study .
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T-cell signatures associated with immune checkpoint blockade toxicity in melanoma patients
Time of Update: 2022-01-24
In this study, we used time-of-flight, single-cell RNA-sequencing, single-cell V(D)J-sequencing, bulk RNA-sequencing, and bulk T-cell receptor (TCR)-sequencing to assess patients receiving anti-PD-1 monotherapy or Peripheral blood samples from melanoma patients treated with anti-PD-1 and anti-CTLA-4 in combination with ICIs were studied .
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Cell: Engineered particles can efficiently deliver gene-editing proteins into mouse cells
Time of Update: 2022-01-24
Now, researchers led by a team at the Broad Institute of MIT and Harvard have developed a way to efficiently implant gene-editing proteins into animal models cells to show the therapeutic effect .
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The latest paper from Sichuan University: Genetic and evolutionary mechanisms affecting the retention of introgression signals in poplar genome hybridization
Time of Update: 2022-01-24
Recently, Professor Wang Jing 's group from the School of Life Sciences of Sichuan University published a research paper entitled Demographic history and natural selection shape patterns of deleterious mutation load and barriers to introgression across Populus genome in the journal Molecular Biology and Evolution .
